U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VPS9 guanine nucleotide exchange factor VPS9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854876, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VPS9
    Official Full Name
    guanine nucleotide exchange factor VPS9
    Primary source
    SGD:S000004563
    Locus tag
    YML097C
    See related
    AllianceGenome:SGD:S000004563; FungiDB:YML097C; VEuPathDB:YML097C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL31; VPT9
    Summary
    Enables guanyl-nucleotide exchange factor activity and ubiquitin binding activity. Involved in several processes, including Golgi to endosome transport; vacuolar transport; and vacuole inheritance. Located in cytosol and early endosome. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VPS9 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (78335..79690, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Arg81p Neighboring gene Taf13p Neighboring gene putative asparagine synthase Neighboring gene DNA repair protein RAD10 Neighboring gene Gim5p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Burd CG, et al. Mol Cell Biol, 1996 May. PMID 8628304, Free PMC Article
    2. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. Hama H, et al. J Biol Chem, 1999 May 21. PMID 10329739
    3. Ubiquitin regulation of the Rab5 family GEF Vps9p. Davies BA, et al. Methods Enzymol, 2005. PMID 16473620
    4. Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Prag G, et al. Cell, 2003 May 30. PMID 12787502
    5. Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9. Shideler T, et al. Mol Biol Cell, 2015 Apr 1. PMID 25673804, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vps9 function in endolysosomal membrane trafficking is promoted by ubiquitin binding by the Vps9 CUE domain
      Title: Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9.
    2. Novel physical interactions between retromer and the Saccharomyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors Muk1 and Vps9 promote their recruitment to endosomes.
      Title: Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes.
    3. Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
      Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to endosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanine nucleotide exchange factor VPS9
    NP_013612.1
    • Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      78335..79690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182457.1 → NP_013612.1  TPA: guanine nucleotide exchange factor VPS9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0I8, P54787
      UniProtKB/TrEMBL
      G2WJW0
      Conserved Domains (3) summary
      smart00167
      Location:205 → 321
      VPS9; Domain present in VPS9
      cd14369
      Location:408 → 449
      CUE_VPS9_like; CUE domain found in vacuolar protein sorting-associated protein 9 (VPS9) and similar proteins
      pfam18151
      Location:80 → 146
      DUF5601; Domain of unknown function (DUF5601)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54787.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous