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    Ggh gamma-glutamyl hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 14590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gghprovided by MGI
    Official Full Name
    gamma-glutamyl hydrolaseprovided by MGI
    Primary source
    MGI:MGI:1329035
    See related
    Ensembl:ENSMUSG00000073987 AllianceGenome:MGI:1329035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gamma-GH
    Summary
    Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in several processes, including response to ethanol; response to insulin; and tetrahydrofolylpolyglutamate metabolic process. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.2), colon adult (RPKM 5.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ggh in Genome Data Viewer
    Location:
    4 A3; 4 7.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (20041963..20066111)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (20041997..20066111)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09707 Neighboring gene RIKEN cDNA 4930598A11 gene Neighboring gene tocopherol (alpha) transfer protein Neighboring gene small cell adhesion glycoprotein pseudogene Neighboring gene Na+/K+ transporting ATPase interacting 3 Neighboring gene STARR-seq mESC enhancer starr_09708 Neighboring gene STARR-positive B cell enhancer mm9_chr4:20118894-20119195 Neighboring gene predicted gene, 52761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Esaki T, et al. Gene, 1998 Sep 28. PMID 9756990
    2. Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter. Esaki T, et al. Gene, 1999 Jun 24. PMID 10393243
    3. Additional organizational features of the murine gamma-glutamyl hydrolase gene. Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter. Masumoto N, et al. Gene, 2001 May 2. PMID 11368914
    4. Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression. Masumoto N, et al. Gene, 2002 May 29. PMID 12095690
    5. High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. Uematsu R, et al. Mol Cell Proteomics, 2005 Dec. PMID 16170054

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-glutamyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-glutamyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamyl hydrolase
    Names
    FGPH
    GH
    conjugase
    folylpolyglutamate hydrolase
    gamma-Glu-x carboxypeptidase
    NP_034411.2
    XP_006537682.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010281.2 → NP_034411.2  gamma-glutamyl hydrolase precursor

      See identical proteins and their annotated locations for NP_034411.2

      Status: VALIDATED

      Source sequence(s)
      AI840300, AI846732, AL732527, BB610405, BE859353, CO044650
      Consensus CDS
      CCDS51126.1
      UniProtKB/Swiss-Prot
      B1AWC1, Q9Z0L7, Q9Z0L8
      UniProtKB/TrEMBL
      B9EKG3
      Related
      ENSMUSP00000095843.4, ENSMUST00000098242.4
      Conserved Domains (2) summary
      pfam07722
      Location:34 → 245
      Peptidase_C26; Peptidase C26
      cl00020
      Location:36 → 305
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      20041963..20066111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537619.4 → XP_006537682.1  gamma-glutamyl hydrolase isoform X1

      Conserved Domains (1) summary
      cl00020
      Location:36 → 231
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0L8.2 GenPept UniProtKB/Swiss-Prot:Q9Z0L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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