Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b3provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 3provided by RGD
Primary source: RGD:621805
See related: EnsemblRapid:ENSRNOG00000019096 AllianceGenome:RGD:621805
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in several processes, including Leydig cell differentiation; response to fungicide; and response to herbicide. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 5.7), Adrenal (RPKM 1.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (1032958..1064283)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (1027229..1058554)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (1579319..1610745, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

11beta-HSD1 is enzymatically coupled to 17beta-HSD3
Title: Role of 11β-OH-C(19) and C(21) steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells.
compared (+)- and (-)-gossypols in the inhibition of 3beta-HSD and 17beta-HSD3 in human and rat testes
Title: The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Mit224 (e-PCR), detects polymorphism
- UniSTS:127038

Hsd17b3 (e-PCR), detects polymorphism
- UniSTS:267002

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables testosterone dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Leydig cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biphenyl metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in insecticide metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in organic acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phenol-containing compound metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in testosterone biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 17-beta-hydroxysteroid dehydrogenase type 3

Names: 17-beta-HSD 3; 17beta-HSD; estradiol 17 beta-dehydrogenase 3; estradiol 17-beta-dehydrogenase 2; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3

NP_446459.1

EC 1.1.1.62

EC 1.1.1.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054007.1 → NP_446459.1 17-beta-hydroxysteroid dehydrogenase type 3

See identical proteins and their annotated locations for NP_446459.1

Status: PROVISIONAL

Source sequence(s)

AF035156

UniProtKB/Swiss-Prot

O54939

UniProtKB/TrEMBL

F1LMA3

Related

ENSRNOP00000025850.1, ENSRNOT00000025850.5

Conserved Domains (2) summary

cd05356
Location:44 → 281

17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

pfam00106
Location:45 → 236

adh_short; short chain dehydrogenase