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    CUP1-1 metallothionein CUP1-1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856450, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CUP1-1
    Official Full Name
    metallothionein CUP1-1
    Primary source
    SGD:S000001095
    Locus tag
    YHR053C
    See related
    AllianceGenome:SGD:S000001095; FungiDB:YHR053C; VEuPathDB:YHR053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CUP1
    Summary
    Enables cadmium ion binding activity; copper ion binding activity; and superoxide dismutase activity. Involved in detoxification of cadmium ion; detoxification of copper ion; and removal of superoxide radicals. Located in cytosol. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CUP1-1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (212535..212720, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VI Neighboring gene Cic1p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of Saccharomyces cerevisiae copper-metallothionein gene in Escherichia coli and characterization of the recombinant protein. Sayers Z, et al. Eur J Biochem, 1993 Mar 1. PMID 8444189
    2. Tandem gene amplification mediates copper resistance in yeast. Fogel S, et al. Proc Natl Acad Sci U S A, 1982 Sep. PMID 6291039, Free PMC Article
    3. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Karin M, et al. Proc Natl Acad Sci U S A, 1984 Jan. PMID 6364141, Free PMC Article
    4. Cloning and expression of a yeast copper metallothionein gene. Butt TR, et al. Gene, 1984 Jan. PMID 6370791
    5. Copper metallothionein of yeast, structure of the gene, and regulation of expression. Butt TR, et al. Proc Natl Acad Sci U S A, 1984 Jun. PMID 6374656, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
      Title: The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
    2. It has been shown that RSC does not affect the nucleosomal occupancy at CUP1. Therefore, transient binding of Ace1p and rapid bursts of transcription at CUP1 may be dependent on short repetitive cycles of nucleosome mobilization.
      Title: Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast.
    3. Data indicate that copy number variation (CNV) is regulated by both promoter activity and acetylation of histone H3 lysine 56 (H3K56ac) and that H3K56ac is required for copper-resistance gene CUP1 CNV and efficient copper adaptation.
      Title: Environmental change drives accelerated adaptation through stimulated copy number variation.
    4. Although interhomolog mitotic recombination in the CUP1 locus is elevated relative to the average genomic region, we found that interhomolog meiotic recombination in the array is reduced compared to most regions
      Title: Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae.
    5. The induction of CUP1 requires the presence of Ace1p and the binding of Ace1p at the CUP1 promoter during activation provides evidence that Ace1p is directly involved in CUP1 induction.
      Title: Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1 activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antioxidant activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadmium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detoxification of copper ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metallothionein CUP1-1
    NP_011922.1
    • Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      212535..212720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179185.1 → NP_011922.1  TPA: metallothionein CUP1-1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL02, P07215, P0CX80, P0CX81
      UniProtKB/TrEMBL
      A0A0A1HAP2, A6ZSW1, B3LSH4, C7GV24, C8Z9J0, G2WFC7
      Conserved Domains (1) summary
      pfam11403
      Location:9 → 47
      Yeast_MT; Yeast metallothionein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX80.1
    P0CX81.1

    Gene LinkOut

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