Odad4 outer dynein arm complex subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odad4provided by MGI
Official Full Name: outer dynein arm complex subunit 4provided by MGI
Primary source: MGI:MGI:1921657
See related: Ensembl:ENSMUSG00000006784 AllianceGenome:MGI:1921657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ttc25; 4933404O19Rik
Summary: Acts upstream of or within brain development; epithelial cilium movement involved in extracellular fluid movement; and outer dynein arm assembly. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Is expressed in node. Used to study primary ciliary dyskinesia 35. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 18.4) and lung adult (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.47 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100436434..100463392)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100545608..100572566)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report of TTC25 as a new member of the outer dynein arms docking machinery in humans and mice
Title: TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.
Ttc25 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucociliary clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to motile cilium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in 9+0 motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in 9+2 motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm docking complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: outer dynein arm-docking complex subunit 4

Names: TPR repeat protein 25; tetratricopeptide repeat domain 25; tetratricopeptide repeat protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363174.1 → NP_001350103.1 outer dynein arm-docking complex subunit 4 isoform 2

Status: VALIDATED

Source sequence(s)

AK161541, BX842667

Consensus CDS

CCDS88255.1

UniProtKB/TrEMBL

B8A5X0

Related

ENSMUSP00000006976.8, ENSMUST00000006976.8

Conserved Domains (3) summary

COG0457
Location:244 → 478

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:14 → 39

TPR; TPR repeat [structural motif]

cl26005
Location:18 → 99

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
NM_028918.3 → NP_083194.2 outer dynein arm-docking complex subunit 4 isoform 1

See identical proteins and their annotated locations for NP_083194.2

Status: VALIDATED

Source sequence(s)

AK016657, AK161541, BX842667, CA463990

Consensus CDS

CCDS36331.1

UniProtKB/Swiss-Prot

A2BI62, Q80X58, Q9D4B2

Related

ENSMUSP00000090355.6, ENSMUST00000092684.12

Conserved Domains (3) summary

sd00006
Location:14 → 39

TPR; TPR repeat [structural motif]

pfam13414
Location:14 → 76

TPR_11; TPR repeat

pfam13424
Location:396 → 466

TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

100436434..100463392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534365.5 → XP_006534428.1 outer dynein arm-docking complex subunit 4 isoform X1

Conserved Domains (3) summary

TIGR00990
Location:18 → 99

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:14 → 39

TPR; TPR repeat [structural motif]

pfam17874
Location:321 → 468

TPR_MalT; MalT-like TPR region