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    Mier3 MIER family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 218613, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mier3provided by MGI
    Official Full Name
    MIER family member 3provided by MGI
    Primary source
    MGI:MGI:2442317
    See related
    Ensembl:ENSMUSG00000032727 AllianceGenome:MGI:2442317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730509D14; D130064H19Rik
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in breast cancer and lung adenocarcinoma. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mier3 in Genome Data Viewer
    Location:
    13 D2.2; 13 63.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111822607..111855130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111686073..111718596)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35655 Neighboring gene STARR-seq mESC enhancer starr_35658 Neighboring gene predicted gene 15290 Neighboring gene STARR-seq mESC enhancer starr_35661 Neighboring gene STARR-seq mESC enhancer starr_35662 Neighboring gene predicted gene 15286 Neighboring gene STARR-positive B cell enhancer ABC_E10815 Neighboring gene STARR-positive B cell enhancer ABC_E7283 Neighboring gene STARR-seq mESC enhancer starr_35666 Neighboring gene STARR-positive B cell enhancer ABC_E386 Neighboring gene SET domain containing 9, pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7284 Neighboring gene STARR-positive B cell enhancer mm9_chr13:112587011-112587312 Neighboring gene STARR-positive B cell enhancer ABC_E1889 Neighboring gene STARR-positive B cell enhancer ABC_E4094 Neighboring gene predicted gene 15327

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117989

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm induction early response protein 3
    Names
    mesoderm induction early response 1, family member 3
    mi-er3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172593.3 → NP_766181.2  mesoderm induction early response protein 3

      See identical proteins and their annotated locations for NP_766181.2

      Status: VALIDATED

      Source sequence(s)
      AC118704, AK083929, AK147427
      Consensus CDS
      CCDS26770.2
      UniProtKB/Swiss-Prot
      Q3SYJ7, Q3UGR9, Q3UHF3, Q8BND7, Q8BSS0
      UniProtKB/TrEMBL
      F7BFR0
      Related
      ENSMUSP00000104895.3, ENSMUST00000109272.9
      Conserved Domains (3) summary
      smart00717
      Location:281 → 328
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:283 → 327
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176 → 225
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      111822607..111855130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517618.3 → XP_006517681.1  mesoderm induction early response protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006517681.1

      UniProtKB/TrEMBL
      B9EHL0, F7BFR0
      Conserved Domains (2) summary
      cd11661
      Location:256 → 300
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149 → 198
      ELM2; ELM2 domain

    2. XM_030247238.2 → XP_030103098.1  mesoderm induction early response protein 3 isoform X3

      UniProtKB/TrEMBL
      F7BFR0
      Related
      ENSMUSP00000104894.3, ENSMUST00000109271.3
      Conserved Domains (2) summary
      cd11661
      Location:282 → 326
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176 → 225
      ELM2; ELM2 domain

    3. XM_006517615.3 → XP_006517678.1  mesoderm induction early response protein 3 isoform X1

      UniProtKB/TrEMBL
      F7BFR0
      Conserved Domains (2) summary
      cd11661
      Location:329 → 373
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:222 → 271
      ELM2; ELM2 domain

    4. XM_006517616.3 → XP_006517679.1  mesoderm induction early response protein 3 isoform X2

      UniProtKB/TrEMBL
      F7BFR0
      Conserved Domains (2) summary
      cd11661
      Location:328 → 372
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:222 → 271
      ELM2; ELM2 domain

    5. XM_036158025.1 → XP_036013918.1  mesoderm induction early response protein 3 isoform X4

      UniProtKB/TrEMBL
      B9EHL0, F7BFR0
      Conserved Domains (2) summary
      cd11661
      Location:256 → 300
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149 → 198
      ELM2; ELM2 domain

    6. XM_006517617.1 → XP_006517680.1  mesoderm induction early response protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006517680.1

      UniProtKB/TrEMBL
      F7BFR0
      Related
      ENSMUSP00000036809.5, ENSMUST00000047412.11
      Conserved Domains (2) summary
      cd11661
      Location:255 → 299
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149 → 198
      ELM2; ELM2 domain

    RNA

    1. XR_382733.3 RNA Sequence

      Related
      ENSMUST00000137268.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHF3.2 GenPept UniProtKB/Swiss-Prot:Q3UHF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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