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    Gtf2a1l general transcription factor IIA, 1-like [ Mus musculus (house mouse) ]

    Gene ID: 71828, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gtf2a1lprovided by MGI
    Official Full Name
    general transcription factor IIA, 1-likeprovided by MGI
    Primary source
    MGI:MGI:1919078
    See related
    Ensembl:ENSMUSG00000024154 AllianceGenome:MGI:1919078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alf; Gtf2a1lf; 1700011N16Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in cognition and transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Part of transcription factor TFIIA complex. Is expressed in central nervous system; early conceptus; gonad; and ureter. Orthologous to human GTF2A1L (general transcription factor IIA subunit 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 130.5) See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2a1l in Genome Data Viewer
    Location:
    17 E4; 17 58.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88972921..89022585)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88665493..88715157)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene stonin 1 Neighboring gene predicted gene, 31704 Neighboring gene STARR-seq mESC enhancer starr_43565 Neighboring gene predicted gene, 31903 Neighboring gene predicted gene, 38460 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene STARR-seq mESC enhancer starr_43566 Neighboring gene STARR-seq mESC enhancer starr_43567 Neighboring gene predicted gene 9407

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A short core promoter drives expression of the ALF transcription factor in reproductive tissues of male and female mice. Han S, et al. Biol Reprod, 2004 Sep. PMID 15151936
    2. Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. Xie W, et al. J Biol Chem, 2002 May 17. PMID 11889132
    3. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Yu C, et al. Nat Commun, 2020 Dec 22. PMID 33353944, Free PMC Article
    4. Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Oyama T, et al. Dev Cell, 2013 Oct 28. PMID 24176642, Free PMC Article
    5. Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice. Xiao L, et al. Gene Expr Patterns, 2006 Apr. PMID 16412700

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
      Title: TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
    2. Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.
      Title: Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.
    3. unique core promoter that is active in both male and female reproductive tissue suggesting ALF may have a regulatory role in male and female gametogenic gene expression programs.
      Title: A short core promoter drives expression of the ALF transcription factor in reproductive tissues of male and female mice.
    4. Endogenous ALF is proteolytically cleaved to give alpha- and beta-subunits and its cleavage site was mapped.
      Title: Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells.
    5. a role for ALF in the assembly and stabilization of initiation complexes in germ cells is likely to be similar or identical to the role of TFIIA in somatic cells.
      Title: The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TFIIA-alpha and beta-like factor
    Names
    TfIIa-alpha/beta-like factor
    general transcription factor II A, 1-like factor
    general transcription factor IIA, 1-like factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023630.2 → NP_076119.2  TFIIA-alpha and beta-like factor

      See identical proteins and their annotated locations for NP_076119.2

      Status: VALIDATED

      Source sequence(s)
      AK005881, BY092414
      Consensus CDS
      CCDS29024.1
      UniProtKB/Swiss-Prot
      Q8R4I4, Q99PM2, Q9DAF4
      Related
      ENSMUSP00000024970.5, ENSMUST00000024970.11
      Conserved Domains (2) summary
      cd07976
      Location:411 → 468
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:10 → 468
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88972921..89022585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246628.3 → XP_011244930.1  TFIIA-alpha and beta-like factor isoform X1

      Conserved Domains (1) summary
      pfam03153
      Location:99 → 347
      TFIIA; Transcription factor IIA, alpha/beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4I4.2 GenPept UniProtKB/Swiss-Prot:Q8R4I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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