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    Fbxl15 F-box and leucine-rich repeat protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 68431, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl15provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 15provided by MGI
    Primary source
    MGI:MGI:1915681
    See related
    Ensembl:ENSMUSG00000025226 AllianceGenome:MGI:1915681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbxo37; 0710008C12Rik
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; dorsal root ganglion; submandibular gland primordium; ventral grey horn; and vibrissa. Orthologous to human FBXL15 (F-box and leucine rich repeat protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 21.3), adrenal adult (RPKM 18.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl15 in Genome Data Viewer
    Location:
    19 C3; 19 38.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46316623..46318885)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46328184..46330446)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene CUE domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E973 Neighboring gene predicted gene, 36493 Neighboring gene microRNA 146b Neighboring gene RIKEN cDNA 2310034G01 gene

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 15
    Names
    F-box only protein 37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378773.1NP_001365702.1  F-box/LRR-repeat protein 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114539
      Conserved Domains (3) summary
      cd09293
      Location:175304
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:125151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:1855
      F-box; F-box domain
    2. NM_133694.2NP_598455.2  F-box/LRR-repeat protein 15 isoform 1

      See identical proteins and their annotated locations for NP_598455.2

      Status: VALIDATED

      Source sequence(s)
      AI594908, AW124512, AW825726, CK791452
      Consensus CDS
      CCDS38007.1
      UniProtKB/Swiss-Prot
      Q3T9R4, Q91W61
      Related
      ENSMUSP00000026256.3, ENSMUST00000026256.9
      Conserved Domains (3) summary
      cd09293
      Location:139268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:6288
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:1855
      F-box; F-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46316623..46318885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161678.1XP_036017571.1  F-box/LRR-repeat protein 15 isoform X1

      UniProtKB/Swiss-Prot
      Q3T9R4, Q91W61
      Related
      ENSMUSP00000137489.2, ENSMUST00000177667.2
      Conserved Domains (3) summary
      cd09293
      Location:139268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:6288
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:1855
      F-box; F-box domain