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    Get4 golgi to ER traffic protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 67604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Get4provided by MGI
    Official Full Name
    golgi to ER traffic protein 4provided by MGI
    Primary source
    MGI:MGI:1914854
    See related
    Ensembl:ENSMUSG00000025858 AllianceGenome:MGI:1914854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cee; 1110007L15Rik
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in several processes, including cytoplasmic sequestering of protein; establishment of protein localization to membrane; and proteolysis involved in protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nuclear lumen. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 65.6), adrenal adult (RPKM 60.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Get4 in Genome Data Viewer
    Location:
    5 G2; 5 78.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139237303..139255806)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139252324..139270050)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4802 Neighboring gene STARR-positive B cell enhancer ABC_E2770 Neighboring gene STARR-positive B cell enhancer ABC_E6389 Neighboring gene STARR-positive B cell enhancer ABC_E9266 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E8825 Neighboring gene STARR-positive B cell enhancer ABC_E6390 Neighboring gene cytochrome c oxidase assembly protein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Mock JY, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535373, Free PMC Article
    2. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic sequestering of protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic sequestering of protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of unfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BAT3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BAT3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi to ER traffic protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163316.1 → NP_001156788.1  Golgi to ER traffic protein 4 homolog isoform 2

      See identical proteins and their annotated locations for NP_001156788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK003551, CJ048159
      Consensus CDS
      CCDS51682.1
      UniProtKB/Swiss-Prot
      Q9D1H7
      Related
      ENSMUSP00000106502.2, ENSMUST00000110878.2
      Conserved Domains (1) summary
      pfam04190
      Location:3 → 237
      DUF410; Protein of unknown function (DUF410)

    2. NM_001359238.1 → NP_001346167.1  Golgi to ER traffic protein 4 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to variant 1.
      Source sequence(s)
      AC125065
      Conserved Domains (1) summary
      pfam04190
      Location:56 → 291
      DUF410; Protein of unknown function (DUF410)

    3. NM_026269.2 → NP_080545.2  Golgi to ER traffic protein 4 homolog isoform 1

      See identical proteins and their annotated locations for NP_080545.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK003551, CJ053487
      Consensus CDS
      CCDS19805.1
      UniProtKB/Swiss-Prot
      Q78J86, Q9D1H7
      Related
      ENSMUSP00000026976.6, ENSMUST00000026976.12
      Conserved Domains (1) summary
      pfam04190
      Location:56 → 292
      DUF410; Protein of unknown function (DUF410)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139237303..139255806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165440.1 → XP_036021333.1  Golgi to ER traffic protein 4 homolog isoform X1

      Conserved Domains (1) summary
      pfam04190
      Location:7 → 145
      DUF410; Protein of unknown function (DUF410)

    2. XM_036165441.1 → XP_036021334.1  Golgi to ER traffic protein 4 homolog isoform X1

      Conserved Domains (1) summary
      pfam04190
      Location:7 → 145
      DUF410; Protein of unknown function (DUF410)

    RNA

    1. XR_004942553.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1H7.2 GenPept UniProtKB/Swiss-Prot:Q9D1H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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