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    Nlrp4a NLR family, pyrin domain containing 4A [ Mus musculus (house mouse) ]

    Gene ID: 243880, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nlrp4aprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Aprovided by MGI
    Primary source
    MGI:MGI:2443697
    See related
    Ensembl:ENSMUSG00000040601 AllianceGenome:MGI:2443697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NALP4; Nalp4a; Nalp-eta; Nalp-ita; E330021B02; E330028A19Rik
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to act upstream of or within defense response. Predicted to be active in cytoplasm. Is expressed in liver and ovary. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Nlrp4a in Genome Data Viewer
    Location:
    7 A3; 7 14.78 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26134538..26175100)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26435113..26476142)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42375 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_18325 Neighboring gene NLR family, pyrin domain containing 9C Neighboring gene STARR-seq mESC enhancer starr_18326 Neighboring gene STARR-seq mESC enhancer starr_18327 Neighboring gene STARR-seq mESC enhancer starr_18328 Neighboring gene STARR-seq mESC enhancer starr_18329 Neighboring gene STARR-seq mESC enhancer starr_18330 Neighboring gene NLR family, pyrin domain containing 9A Neighboring gene STARR-seq mESC enhancer starr_18331 Neighboring gene vomeronasal 1 receptor 185

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
    2. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
    3. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    4. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747
    5. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, et al. Genome Res, 2003 Jun. PMID 12819136, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 4A
    Names
    NACHT, leucine rich repeat and PYD containing 4A
    NACHT/LRR/pyrin domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362156.2 → NP_001349085.1  NACHT, LRR and PYD domains-containing protein 4A

      Status: VALIDATED

      Source sequence(s)
      AC132428
      Consensus CDS
      CCDS21003.1
      UniProtKB/Swiss-Prot
      Q8BU40
      UniProtKB/TrEMBL
      A0A0U1RPM5, B2RUQ7
      Related
      ENSMUSP00000112441.2, ENSMUST00000119386.8
      Conserved Domains (5) summary
      cd08320
      Location:10 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:891 → 911
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:692 → 720
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:149 → 316
      NACHT; NACHT domain
      cl26161
      Location:692 → 953
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_172896.4 → NP_766484.1  NACHT, LRR and PYD domains-containing protein 4A

      See identical proteins and their annotated locations for NP_766484.1

      Status: VALIDATED

      Source sequence(s)
      AC132428
      Consensus CDS
      CCDS21003.1
      UniProtKB/Swiss-Prot
      Q8BU40
      UniProtKB/TrEMBL
      A0A0U1RPM5, B2RUQ7
      Related
      ENSMUSP00000066841.4, ENSMUST00000068767.10
      Conserved Domains (5) summary
      cd08320
      Location:10 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:891 → 911
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:692 → 720
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:149 → 316
      NACHT; NACHT domain
      cl26161
      Location:692 → 953
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26134538..26175100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250567.1 → XP_011248869.1  NACHT, LRR and PYD domains-containing protein 4A isoform X2

      Related
      ENSMUST00000146534.8
      Conserved Domains (4) summary
      cd08320
      Location:10 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      pfam05729
      Location:149 → 316
      NACHT; NACHT domain
      pfam17776
      Location:451 → 564
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:393 → 449
      NOD2_WH; NOD2 winged helix domain

    2. XM_030242565.1 → XP_030098425.1  NACHT, LRR and PYD domains-containing protein 4A isoform X1

      Conserved Domains (4) summary
      cd08320
      Location:10 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      pfam05729
      Location:162 → 329
      NACHT; NACHT domain
      pfam17776
      Location:464 → 577
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:406 → 462
      NOD2_WH; NOD2 winged helix domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU40.1 GenPept UniProtKB/Swiss-Prot:Q8BU40

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