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    Car11 carbonic anhydrase 11 [ Mus musculus (house mouse) ]

    Gene ID: 12348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Car11provided by MGI
    Official Full Name
    carbonic anhydrase 11provided by MGI
    Primary source
    MGI:MGI:1336193
    See related
    Ensembl:ENSMUSG00000003273 AllianceGenome:MGI:1336193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca11
    Summary
    Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; ear; eye; genitourinary system; and nervous system. Orthologous to human CA11 (carbonic anhydrase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 49.8), frontal lobe adult (RPKM 43.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Car11 in Genome Data Viewer
    Location:
    7 B3; 7 29.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45348537..45354106)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45699171..45704687)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene D site albumin promoter binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene sphingosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene ribosomal protein L18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI. Taniuchi K, et al. Brain Res Mol Brain Res, 2002 Dec 30. PMID 12531530
    2. Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. Lovejoy DA, et al. Genomics, 1998 Dec 15. PMID 9878252
    3. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Verlander JW, et al. Am J Physiol Renal Physiol, 2003 Feb. PMID 12388412
    4. Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. Reibring CG, et al. PLoS One, 2014. PMID 24789143, Free PMC Article
    5. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Wu L, et al. Dev Dyn, 2013 Mar. PMID 23233153

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables carbonate dehydratase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase-related protein 11
    Names
    CA-RP II
    CA-RP XI
    CA-XI
    CARP XI
    CARP-2
    carbonic anhydrase-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368349.2 → NP_001355278.1  carbonic anhydrase-related protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167242
      UniProtKB/TrEMBL
      Q3USV1

    2. NM_009800.5 → NP_033930.1  carbonic anhydrase-related protein 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033930.1

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS21259.1
      UniProtKB/Swiss-Prot
      O70354, Q8VEA9
      UniProtKB/TrEMBL
      Q3USV1, Q541E9
      Related
      ENSMUSP00000003360.8, ENSMUST00000003360.10
      Conserved Domains (1) summary
      cd03121
      Location:48 → 304
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    RNA

    1. NR_177998.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167242

    2. NR_177999.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167242

    3. NR_178000.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167242

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45348537..45354106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540588.4 → XP_006540651.1  carbonic anhydrase-related protein 11 isoform X1

      UniProtKB/TrEMBL
      Q3USV1
      Conserved Domains (1) summary
      cd03121
      Location:48 → 304
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    2. XM_006540589.3 → XP_006540652.1  carbonic anhydrase-related protein 11 isoform X2

      UniProtKB/TrEMBL
      Q3USV1
      Conserved Domains (1) summary
      cd03121
      Location:23 → 279
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70354.2 GenPept UniProtKB/Swiss-Prot:O70354

    Gene LinkOut

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