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    Drd4 dopamine receptor D4 [ Mus musculus (house mouse) ]

    Gene ID: 13491, updated on 9-Dec-2024

    Summary

    Official Symbol
    Drd4provided by MGI
    Official Full Name
    dopamine receptor D4provided by MGI
    Primary source
    MGI:MGI:94926
    See related
    Ensembl:ENSMUSG00000025496 AllianceGenome:MGI:94926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4R; Drd-4
    Summary
    Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in regulation of circadian rhythm and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 6.8), testis adult (RPKM 3.5) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Drd4 in Genome Data Viewer
    Location:
    7 F5; 7 86.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140871931..140874868)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141291974..141296464)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5 Neighboring gene secretin Neighboring gene STARR-seq mESC enhancer starr_20485 Neighboring gene DEAF1, transcription factor Neighboring gene STARR-seq mESC enhancer starr_20486 Neighboring gene predicted gene, 53347 Neighboring gene STARR-positive B cell enhancer ABC_E4985 Neighboring gene transmembrane protein 80

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled serotonin receptor activity  
    enables SH3 domain binding  
    enables SH3 domain binding  
    enables dopamine binding  
    enables dopamine binding  
    enables dopamine neurotransmitter receptor activity  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go  
    enables epinephrine binding  
    enables epinephrine binding  
    enables heterocyclic compound binding  
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables neurotransmitter receptor activity  
    enables norepinephrine binding  
    enables norepinephrine binding  
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway PubMed 
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within adult locomotory behavior PubMed 
    involved_in arachidonate secretion  
    involved_in arachidonate secretion  
    involved_in associative learning  
    involved_in behavioral fear response  
    acts_upstream_of_or_within behavioral response to cocaine PubMed 
    involved_in chemical synaptic transmission  
    acts_upstream_of_or_within fear response PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in modulation of inhibitory postsynaptic potential  
    involved_in negative regulation of protein secretion  
    involved_in negative regulation of protein secretion  
    involved_in negative regulation of synaptic transmission  
    involved_in negative regulation of synaptic transmission, GABAergic  
    involved_in negative regulation of vascular associated smooth muscle cell migration  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in negative regulation of voltage-gated calcium channel activity  
    involved_in olfactory learning  
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    acts_upstream_of positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of kinase activity  
    involved_in positive regulation of penile erection  
    involved_in positive regulation of sodium:proton antiporter activity  
    involved_in prepulse inhibition  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in regulation of calcium-mediated signaling  
    involved_in regulation of circadian rhythm PubMed 
    acts_upstream_of_or_within regulation of dopamine metabolic process PubMed 
    involved_in regulation of neurotransmitter secretion  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of protein kinase A signaling  
    acts_upstream_of_or_within response to amphetamine PubMed 
    involved_in response to histamine  
    involved_in response to histamine  
    involved_in rhythmic process  
    involved_in short-term memory  
    involved_in synaptic transmission, dopaminergic  
    involved_in synaptic transmission, dopaminergic  
    Items 1 - 25 of 50
    Items 1 - 20 of 33
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in Golgi apparatus  
    located_in axon  
    located_in axon terminus  
    located_in cell cortex  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane  
    is_active_in dendrite  
    located_in dendrite  
    located_in dendrite terminus  
    located_in dendritic microtubule  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in endoplasmic reticulum  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in mitochondrion  
    located_in neuronal cell body  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in postsynaptic membrane  
    located_in presynapse  
    is_active_in presynaptic membrane  
    located_in synapse  
    located_in terminal bouton  
    Items 1 - 20 of 33

    General protein information

    Preferred Names
    D(4) dopamine receptor
    Names
    d(2C) dopamine receptor
    dopamine receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412325.1NP_001399254.1  D(4) dopamine receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163434
    2. NM_001412326.1NP_001399255.1  D(4) dopamine receptor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163434
    3. NM_007878.4NP_031904.1  D(4) dopamine receptor isoform 1

      See identical proteins and their annotated locations for NP_031904.1

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS22007.1
      UniProtKB/Swiss-Prot
      O35838, P51436, Q7TT80, Q8BXS4
      Related
      ENSMUSP00000026569.5, ENSMUST00000026569.6
      Conserved Domains (1) summary
      pfam00001
      Location:48368
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140871931..140874868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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