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    Kctd20 potassium channel tetramerization domain containing 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294307, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kctd20provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 20provided by RGD
    Primary source
    RGD:1309887
    See related
    EnsemblRapid:ENSRNOG00000000517 AllianceGenome:RGD:1309887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309887
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of phosphorylation and signal transduction. Predicted to be active in cytoplasm. Orthologous to human KCTD20 (potassium channel tetramerization domain containing 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 97.1), Spleen (RPKM 95.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd20 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7017480..7034440)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7015828..7032766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6205897..6222818)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483864 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene serine/threonine kinase 38 Neighboring gene uncharacterized LOC134483866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KCTD20, a relative of BTBD10, is a positive regulator of Akt. Nawa M, et al. BMC Biochem, 2013 Oct 24. PMID 24156551, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD20
    Names
    potassium channel tetramerisation domain containing 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399470.1 → NP_001386399.1  BTB/POZ domain-containing protein KCTD20

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0U1RRY2, A6JJS9
      Conserved Domains (2) summary
      cd18386
      Location:114 → 217
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:279 → 318
      PH-like; Pleckstrin homology-like domain

    2. NM_001399471.1 → NP_001386400.1  BTB/POZ domain-containing protein KCTD20

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0U1RRY2, A6JJS9
      Related
      ENSRNOP00000075859.1, ENSRNOT00000092333.3
      Conserved Domains (2) summary
      cd18386
      Location:114 → 217
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:279 → 318
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7017480..7034440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601866.3 → XP_017457355.1  BTB/POZ domain-containing protein KCTD20 isoform X4

      Conserved Domains (2) summary
      cl38908
      Location:1 → 73
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl17171
      Location:135 → 174
      PH-like; Pleckstrin homology-like domain

    2. XM_006256152.5 → XP_006256214.1  BTB/POZ domain-containing protein KCTD20 isoform X3

      See identical proteins and their annotated locations for XP_006256214.1

      UniProtKB/TrEMBL
      A6JJT0
      Conserved Domains (2) summary
      cd18386
      Location:42 → 145
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:207 → 246
      PH-like; Pleckstrin homology-like domain

    3. XM_006256151.5 → XP_006256213.1  BTB/POZ domain-containing protein KCTD20 isoform X2

      See identical proteins and their annotated locations for XP_006256213.1

      Related
      ENSRNOP00000109520.1, ENSRNOT00000162356.1
      Conserved Domains (2) summary
      smart00225
      Location:109 → 197
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam16017
      Location:141 → 370
      BTB_3; BTB/POZ domain

    4. XM_039099248.2 → XP_038955176.1  BTB/POZ domain-containing protein KCTD20 isoform X3

      UniProtKB/TrEMBL
      A6JJT0
      Conserved Domains (2) summary
      cd18386
      Location:42 → 145
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:207 → 246
      PH-like; Pleckstrin homology-like domain

    5. XM_039099247.2 → XP_038955175.1  BTB/POZ domain-containing protein KCTD20 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RRY2, A6JJS9, D3ZGN4
      Conserved Domains (2) summary
      cd18386
      Location:114 → 217
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:279 → 318
      PH-like; Pleckstrin homology-like domain

    6. XM_063279030.1 → XP_063135100.1  BTB/POZ domain-containing protein KCTD20 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RRY2, A6JJS9
    Nucleotide Protein Strain
    Heading Accession and Version

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