Lgsn lengsin, lens protein with glutamine synthetase domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgsnprovided by MGI
Official Full Name: lengsin, lens protein with glutamine synthetase domainprovided by MGI
Primary source: MGI:MGI:2672844
See related: Ensembl:ENSMUSG00000050217 AllianceGenome:MGI:2672844
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lgs; Gluld1; lengsin
Summary: Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Located in plasma membrane. Orthologous to human LGSN (lengsin, lens protein with glutamine synthetase domain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 5.5) See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 11.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (31215362..31243806)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (31176281..31204725)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the ZNRF1-GS system may play an important role in correlating Schwann cell metabolism with its differentiation.
Title: Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.
Lengsin interacts with intermediate filament proteins of the eye lens and is associated with terminal differentiation of fiber cells
Title: A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens.
lengsin may act as a component of the cytoskeleton itself or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens.
Title: A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables glutamine synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamine synthetase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in glutamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine biosynthetic process	IEA Inferred from Electronic Annotation more info
NOT involved_in nitrogen utilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lengsin

Names: glutamate-ammonia ligase (glutamine synthase) domain containing 1; glutamate-ammonia ligase (glutamine synthetase) domain containing 1; glutamate-ammonia ligase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153601.1 → NP_705829.1 lengsin

See identical proteins and their annotated locations for NP_705829.1

Status: PROVISIONAL

Source sequence(s)

AF545851

Consensus CDS

CCDS14859.1

UniProtKB/Swiss-Prot

Q149K1, Q8CIX8

Related

ENSMUSP00000059871.8, ENSMUST00000062560.14

Conserved Domains (3) summary

COG0174
Location:130 → 547

GlnA; Glutamine synthetase [Amino acid transport and metabolism]

pfam00120
Location:237 → 561

Gln-synt_C; Glutamine synthetase, catalytic domain

pfam03951
Location:140 → 225

Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

31215362..31243806

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254460.1 → XP_030110320.1 lengsin isoform X1

Conserved Domains (2) summary

pfam00120
Location:81 → 405

Gln-synt_C; Glutamine synthetase, catalytic domain

pfam03951
Location:42 → 69

Gln-synt_N; Glutamine synthetase, beta-Grasp domain
XM_030254462.1 → XP_030110322.1 lengsin isoform X1

Conserved Domains (2) summary

pfam00120
Location:81 → 405

Gln-synt_C; Glutamine synthetase, catalytic domain

pfam03951
Location:42 → 69

Gln-synt_N; Glutamine synthetase, beta-Grasp domain