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    Nab1 Ngfi-A binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17936, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nab1provided by MGI
    Official Full Name
    Ngfi-A binding protein 1provided by MGI
    Primary source
    MGI:MGI:107564
    See related
    Ensembl:ENSMUSG00000002881 AllianceGenome:MGI:107564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; lung epithelium; and paraxial mesenchyme. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.5), liver E18 (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nab1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52494146..52539553, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52455849..52500712, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00897 Neighboring gene STARR-seq mESC enhancer starr_00898 Neighboring gene predicted gene, 31955 Neighboring gene STARR-seq mESC enhancer starr_00899 Neighboring gene STARR-positive B cell enhancer ABC_E9178 Neighboring gene predicted gene, 23460 Neighboring gene STARR-positive B cell enhancer ABC_E7723 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ribosomal protein S27A, pseudogene 1 Neighboring gene predicted gene 53065

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel mutants of NAB corepressors enhance activation by Egr transactivators. Svaren J, et al. EMBO J, 1998 Oct 15. PMID 9774344, Free PMC Article
    2. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Buitrago M, et al. Nat Med, 2005 Aug. PMID 16025126
    3. Active gene repression by the Egr2.NAB complex during peripheral nerve myelination. Mager GM, et al. J Biol Chem, 2008 Jun 27. PMID 18456662, Free PMC Article
    4. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo MW, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624335, Free PMC Article
    5. Nab proteins are essential for peripheral nervous system myelination. Le N, et al. Nat Neurosci, 2005 Jul. PMID 16136673

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.
      Title: Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
    2. Egr2 directly represses genes during myelination in conjunction with NAB corepressors
      Title: Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
    3. Nab1 is a potent inhibitor of cardiac growth in response to pathological stimuli in vivo.
      Title: The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
    4. Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
      Title: Nab proteins are essential for peripheral nervous system myelination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endochondral ossification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of epidermis development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NGFI-A-binding protein 1
    Names
    EGR-1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420345.1 → NP_001407274.1  NGFI-A-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164428
      UniProtKB/Swiss-Prot
      Q61122, Q99J24

    2. NM_001420346.1 → NP_001407275.1  NGFI-A-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164428
      UniProtKB/TrEMBL
      A0A087WSU4

    3. NM_001420347.1 → NP_001407276.1  NGFI-A-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164428
      UniProtKB/TrEMBL
      A0A087WSU4
      Related
      ENSMUSP00000141191.2, ENSMUST00000186764.7

    4. NM_008667.4 → NP_032693.2  NGFI-A-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_032693.2

      Status: VALIDATED

      Source sequence(s)
      AC164428
      Consensus CDS
      CCDS14944.1
      UniProtKB/Swiss-Prot
      Q61122, Q99J24
      UniProtKB/TrEMBL
      E9PZ64
      Related
      ENSMUSP00000066696.8, ENSMUST00000069792.14
      Conserved Domains (3) summary
      pfam04905
      Location:189 → 316
      NCD2; NAB conserved region 2 (NCD2)
      pfam04902
      Location:321 → 485
      Nab1; Conserved region in Nab1
      pfam04904
      Location:6 → 83
      NCD1; NAB conserved region 1 (NCD1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52494146..52539553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61122.2 GenPept UniProtKB/Swiss-Prot:Q61122

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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