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    Cyp2b23 cytochrome P450, family 2, subfamily b, polypeptide 23 [ Mus musculus (house mouse) ]

    Gene ID: 243881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp2b23provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily b, polypeptide 23provided by MGI
    Primary source
    MGI:MGI:3646735
    See related
    Ensembl:ENSMUSG00000040650 AllianceGenome:MGI:3646735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG243881
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 1.4), duodenum adult (RPKM 1.1) and 6 other tissues See more
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    Genomic context

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    See Cyp2b23 in Genome Data Viewer
    Location:
    7 A3; 7 15.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26364652..26389788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26665227..26686430, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 9A Neighboring gene STARR-seq mESC enhancer starr_18331 Neighboring gene vomeronasal 1 receptor 185 Neighboring gene STARR-seq mESC enhancer starr_18334 Neighboring gene STARR-seq mESC enhancer starr_18335 Neighboring gene STARR-seq mESC enhancer starr_18336 Neighboring gene STARR-seq mESC enhancer starr_18337 Neighboring gene predicted gene 45034 Neighboring gene predicted gene, 51442 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Damiri B, et al. Toxicol Sci, 2012 Feb. PMID 22083726, Free PMC Article
    2. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Lundgren M, et al. Toxicology, 2007 Dec 5. PMID 17964055
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.
      Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estrogen 2-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 16-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily b, polypeptide 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081148.1 → NP_001074617.1  cytochrome P450, family 2, subfamily b, polypeptide 23 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC138334
      Consensus CDS
      CCDS39846.1
      UniProtKB/TrEMBL
      E9Q593
      Related
      ENSMUSP00000076578.7, ENSMUST00000077356.7
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26364652..26389788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153083.1 → XP_036008976.1  cytochrome P450, family 2, subfamily b, polypeptide 23 isoform X1

      Conserved Domains (1) summary
      cd20672
      Location:8 → 432
      CYP2B; cytochrome P450 family 2, subfamily B
    Nucleotide Protein
    Heading Accession and Version

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