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    Trpm5 transient receptor potential cation channel, subfamily M, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 56843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trpm5provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 5provided by MGI
    Primary source
    MGI:MGI:1861718
    See related
    Ensembl:ENSMUSG00000009246 AllianceGenome:MGI:1861718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtr1; Ltrpc5; LTrpC-5; 9430099A16Rik
    Summary
    Enables calcium-activated cation channel activity; potassium channel activity; and sodium channel activity. Involved in monoatomic ion transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in dendrite; membrane; and neuronal cell body. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including ganglia; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Orthologous to human TRPM5 (transient receptor potential cation channel subfamily M member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 15.6), small intestine adult (RPKM 3.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpm5 in Genome Data Viewer
    Location:
    7 F5; 7 88.11 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142625266..142648379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143071529..143094642, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6616 Neighboring gene STARR-seq mESC enhancer starr_20520 Neighboring gene STARR-positive B cell enhancer ABC_E6617 Neighboring gene STARR-seq mESC enhancer starr_20521 Neighboring gene expressed sequence R74862 Neighboring gene nonconserved acetylation island sequence M93 enhancer Neighboring gene CD81 antigen Neighboring gene tumor-suppressing subchromosomal transferable fragment 4 Neighboring gene VISTA enhancer mm183 Neighboring gene STARR-seq mESC enhancer starr_20525 Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene predicted gene 28821 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene STARR-positive B cell enhancer ABC_E10485

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transduction channel TRPM5 is gated by intracellular calcium in taste cells. Zhang Z, et al. J Neurosci, 2007 May 23. PMID 17522321, Free PMC Article
    2. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Talavera K, et al. Nature, 2005 Dec 15. PMID 16355226
    3. Trpm5 null mice respond to bitter, sweet, and umami compounds. Damak S, et al. Chem Senses, 2006 Mar. PMID 16436689
    4. Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction. Wu H, et al. Sci China Life Sci, 2020 Nov. PMID 32303962
    5. A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice. Eddy MC, et al. Chem Senses, 2012 Jun. PMID 21987728, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
      Title: Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
    2. Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
      Title: Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
    3. Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction.
      Title: Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction.
    4. Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium.
      Title: Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium.
    5. TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure.
      Title: TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure.
    6. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
      Title: TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
    7. TRPM5(-/-) mice showed a lowered aversion to high-salt diet and developed salt-induced hypertension.
      Title: Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension.
    8. Both TRPM4 and TRPM5 are required for normal responses to bitter, sweet, and umami stimuli.
      Title: TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
    9. This physiological and behavioral results indicate that TRPM5-MCs play a protective role in maintaining the olfactory function of the mammalian main olfactory epithelium.
      Title: Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment.
    10. conclude that nAChR subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol
      Title: Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-activated cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 5
    Names
    MLSN1- and TRP-related gene 1 protein
    long transient receptor potential channel 5
    long transient receptor potential-related channel 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020277.2 → NP_064673.2  transient receptor potential cation channel subfamily M member 5

      See identical proteins and their annotated locations for NP_064673.2

      Status: VALIDATED

      Source sequence(s)
      AB039952, AF228681, AK044908
      Consensus CDS
      CCDS52462.1
      UniProtKB/Swiss-Prot
      A3KN89, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4, Q9JJH7
      UniProtKB/TrEMBL
      Q8BS44
      Related
      ENSMUSP00000009390.4, ENSMUST00000009390.10
      Conserved Domains (2) summary
      TIGR00870
      Location:711 → 1022
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:49 → 267
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142625266..142648379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508645.1 → XP_006508708.1  transient receptor potential cation channel subfamily M member 5 isoform X1

      See identical proteins and their annotated locations for XP_006508708.1

      UniProtKB/Swiss-Prot
      A3KN89, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4, Q9JJH7
      UniProtKB/TrEMBL
      Q8BS44
      Conserved Domains (2) summary
      TIGR00870
      Location:711 → 1022
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:49 → 267
      LSDAT_euk; SLOG in TRPM

    2. XM_030242820.1 → XP_030098680.1  transient receptor potential cation channel subfamily M member 5 isoform X3

      Related
      ENSMUST00000150589.8
      Conserved Domains (1) summary
      TIGR00870
      Location:325 → 636
      trp; transient-receptor-potential calcium channel protein

    3. XM_006508646.4 → XP_006508709.1  transient receptor potential cation channel subfamily M member 5 isoform X2

      See identical proteins and their annotated locations for XP_006508709.1

      UniProtKB/TrEMBL
      Q8BS44
      Related
      ENSMUSP00000114302.2, ENSMUST00000150867.2
      Conserved Domains (2) summary
      pfam00520
      Location:741 → 872
      Ion_trans; Ion transport protein
      cl39032
      Location:49 → 267
      LSDAT_euk; SLOG in TRPM

    RNA

    1. XR_003946530.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJH7.1 GenPept UniProtKB/Swiss-Prot:Q9JJH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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