Mir374b microRNA 374b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir374bprovided by MGI
Official Full Name: microRNA 374bprovided by MGI
Primary source: MGI:MGI:3629958
See related: Ensembl:ENSMUSG00000076269 miRBase:MI0004125; AllianceGenome:MGI:3629958
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mir374; Mirn374; mir-374b; mmu-mir-374; mmu-mir-374b
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: X D; X 46.22 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (102616666..102616760, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (103573060..103573154, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sevoflurane activates MEF2D-mediated Wnt/beta-catenin signaling pathway via microRNA-374b-5p to affect renal ischemia/reperfusion injury.
Title: Sevoflurane activates MEF2D-mediated Wnt/β-catenin signaling pathway via microRNA-374b-5p to affect renal ischemia/reperfusion injury.
Suppression of FoxO1 mRNA by beta2 -adrenoceptor-cAMP signaling through miR-374b-5p and miR-7a-1-3p in C2C12 myotubes.
Title: Suppression of FoxO1 mRNA by β(2) -adrenoceptor-cAMP signaling through miR-374b-5p and miR-7a-1-3p in C2C12 myotubes.
Down-regulation of lncRNA SNHG5 relieves sepsis-induced acute kidney injury by regulating the miR-374a-3p/TLR4/NF-kappaB pathway.
Title: Down-regulation of lncRNA SNHG5 relieves sepsis-induced acute kidney injury by regulating the miR-374a-3p/TLR4/NF-κB pathway.
MiR-374b-5p Regulates T Cell Differentiation and Is Associated with rEg.P29 Immunity.
Title: MiR-374b-5p Regulates T Cell Differentiation and Is Associated with rEg.P29 Immunity.
these results demonstrated that, by inhibiting the activity of DTNA-mediated Notch1 axis, miR-374 could protect against myocardial I/R injury in mice after thoracic epidural anesthesia
Title: Protective role of microRNA-374 against myocardial ischemia-reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha-mediated Notch1 axis.
miR-374b can promote osteogenic differentiation of MSCs by degrading PTEN, thereby promoting fracture healing.
Title: MiR-374b promotes osteogenic differentiation of MSCs by degrading PTEN and promoting fracture healing.
miR-374b regulates the proliferation and differentiation of neural stem cells through targeting Hes1. Overexpression of Hes1 reverses the effect of miR-374b overexpression on neural stem cells differentiation.
Title: MicroRNA-374b promotes the proliferation and differentiation of neural stem cells through targeting Hes1.
findings identified miR-374b directly targets Myf6 and negatively regulates myogenesis
Title: MicroRNA, miR-374b, directly targets Myf6 and negatively regulates C2C12 myoblasts differentiation.
Results suggest the existence of a coordinated mechanism by miR-23a and miR-374 to down regulate Brn3b and ultimately regulate the development of retinal ganglion cells from their precursors
Title: Developmental wave of Brn3b expression leading to RGC fate specification is synergistically maintained by miR-23a and miR-374.
The genetic mutations in the calcium-sensing receptor from patients with autosomal dominant hypocalcemia repressed the transcription of miR-9 and miR-374 genes.
Title: Epigenetic regulation of microRNAs controlling CLDN14 expression as a mechanism for renal calcium handling.

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.