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    MIR17HG miR-17-92a-1 cluster host gene [ Homo sapiens (human) ]

    Gene ID: 407975, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIR17HGprovided by HGNC
    Official Full Name
    miR-17-92a-1 cluster host geneprovided by HGNC
    Primary source
    HGNC:HGNC:23564
    See related
    Ensembl:ENSG00000215417 MIM:609415; AllianceGenome:HGNC:23564
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIHG1; MIRH1; MIRHG1; C13orf25; LINC00048; miR-17-92; NCRNA00048
    Summary
    This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 25 other tissues See more
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    Genomic context

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    See MIR17HG in Genome Data Viewer
    Location:
    13q31.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (91347687..91354577)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (90550261..90557153)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (91999941..92006831)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370313 Neighboring gene uncharacterized LOC105370314 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:91977821-91978041 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:91988812-91988986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5431 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:92001527-92002074 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:92000979-92001526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7863 Neighboring gene peptidylprolyl isomerase A pseudogene 23 Neighboring gene uncharacterized LOC124903189 Neighboring gene Sharpr-MPRA regulatory region 6090 Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1 Neighboring gene microRNA 18a Neighboring gene microRNA 19a Neighboring gene microRNA 20a Neighboring gene microRNA 17 Neighboring gene glypican 5 Neighboring gene RNA, U4atac small nuclear 3, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis. Zhang W, et al. Cell Death Dis, 2018 May 1. PMID 29752469, Free PMC Article
    2. MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells. Jablonska E, et al. Exp Hematol, 2017 Feb. PMID 27720936
    3. The role of the miR-17-92 cluster in neurogenesis and angiogenesis in the central nervous system of adults. Yang P, et al. J Neurosci Res, 2017 Aug. PMID 27869313
    4. The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma. Schwentner R, et al. Oncotarget, 2017 Feb 14. PMID 28030800, Free PMC Article
    5. MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92. Li Y, et al. PLoS One, 2011. PMID 22022595, Free PMC Article

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit.
      Title: LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit.
    2. Association between Mir-17-92 gene promoter polymorphisms and depression in a Chinese population.
      Title: Association between Mir-17-92 gene promoter polymorphisms and depression in a Chinese population.
    3. Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.
      Title: Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.
    4. Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.
      Title: Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.
    5. LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
      Title: LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
    6. Exosomal miR-17-92 derived from human mesenchymal stem cells promotes wound healing by enhancing angiogenesis and inhibiting endothelial cell ferroptosis.
      Title: Exosomal miR-17-92 derived from human mesenchymal stem cells promotes wound healing by enhancing angiogenesis and inhibiting endothelial cell ferroptosis.
    7. Prognostic Value of the miR-17~92 Cluster in Chronic Lymphocytic Leukemia.
      Title: Prognostic Value of the miR-17~92 Cluster in Chronic Lymphocytic Leukemia.
    8. The miR-17-92 cluster: Yin and Yang in human cancers.
      Title: The miR-17-92 cluster: Yin and Yang in human cancers.
    9. Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population.
      Title: Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population.
    10. Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature.
      Title: Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature.
    Submit: New GeneRIF Correction See all GeneRIFs (116)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • MIR17 host gene (non-protein coding)
    • long intergenic non-protein coding RNA 48
    • miR-17-92 cluster host gene (non-protein coding)
    • microRNA host gene (non-protein coding) 1
    • microRNA host gene 1 (non-protein coding)
    • mir-17-92 microRNA cluster

    Clone Names

    • FLJ14178, MGC126270

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac right ventricle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lung growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of negative regulation of B cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outflow tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of muscle hyperplasia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of regulation of B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032702.1 RefSeqGene

      Range
      5001..11756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_027349.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two internal segments compared to variant 1. This transcript lacks the MIR17-92 cluster of miRNAs found in variant 1.
      Source sequence(s)
      AL138714, AL162375
      Related
      ENST00000710420.1

    2. NR_027350.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and contains the MIR17-92 cluster of miRNAs.
      Source sequence(s)
      AL138714, AL162375
      Related
      ENST00000582141.6

    3. NR_197388.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138714, AL162375

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      91347687..91354577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      90550261..90557153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213723.1: Suppressed sequence

      Description
      NM_213723.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NM_213724.1: Suppressed sequence

      Description
      NM_213724.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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