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    SLC25A21 solute carrier family 25 member 21 [ Homo sapiens (human) ]

    Gene ID: 89874, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC25A21provided by HGNC
    Official Full Name
    solute carrier family 25 member 21provided by HGNC
    Primary source
    HGNC:HGNC:14411
    See related
    Ensembl:ENSG00000183032 MIM:607571; AllianceGenome:HGNC:14411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ODC; ODC1; MTDPS18
    Summary
    SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
    Expression
    Biased expression in esophagus (RPKM 5.4), salivary gland (RPKM 2.6) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC25A21 in Genome Data Viewer
    Location:
    14q13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (36677921..37172606, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (30867261..31362039, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (37147126..37641811, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37116557-37117386 Neighboring gene uncharacterized LOC105370455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:37123150-37123888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:37125365-37126102 Neighboring gene PAX9 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37131533-37132044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37132045-37132554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37132555-37133065 Neighboring gene NANOG hESC enhancer GRCh37_chr14:37153788-37154289 Neighboring gene paired box 9 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:37271122-37272321 Neighboring gene NANOG hESC enhancer GRCh37_chr14:37274394-37274895 Neighboring gene uncharacterized LOC107984668 Neighboring gene microRNA 4503 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:37549523-37550722 Neighboring gene Sharpr-MPRA regulatory region 11704 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:37636900-37637452 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37640926-37641505 Neighboring gene SLC25A21 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:37641506-37642084 Neighboring gene RNA, U6 small nuclear 273, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr14:37708438-37708614 Neighboring gene VISTA enhancer hs593 Neighboring gene mirror-image polydactyly 1 Neighboring gene uncharacterized LOC107984702

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mitochondrial DNA depletion syndrome 18
    MedGen: C5394140 OMIM: 618811 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of solute carrier family 25, member 21 (SLC25A21) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126570

    General protein information

    Preferred Names
    mitochondrial 2-oxodicarboxylate carrier
    Names
    mitochondrial 2-oxoadipate carrier
    oxodicarboxylate carrier
    solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
    solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171170.2NP_001164641.1  mitochondrial 2-oxodicarboxylate carrier isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a split 3' exon, as compared to variant 1. The resulting isoform (2) lacks the last aa, as compared to isoform 1.
      Source sequence(s)
      AJ278148, AK289575, AL079303
      Consensus CDS
      CCDS55913.1
      UniProtKB/Swiss-Prot
      Q9BQT8
      Related
      ENSP00000451873.1, ENST00000555449.5
      Conserved Domains (2) summary
      PTZ00168
      Location:12283
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:15105
      Mito_carr; Mitochondrial carrier protein
    2. NM_030631.4NP_085134.1  mitochondrial 2-oxodicarboxylate carrier isoform 1

      See identical proteins and their annotated locations for NP_085134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes isoform 1.
      Source sequence(s)
      AJ278148, AL079303
      Consensus CDS
      CCDS9663.1
      UniProtKB/Swiss-Prot
      A8K0L0, G3V4L5, Q3MJ99, Q9BQT8
      Related
      ENSP00000329452.5, ENST00000331299.6
      Conserved Domains (1) summary
      pfam00153
      Location:15105
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      36677921..37172606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431871.1XP_047287827.1  mitochondrial 2-oxodicarboxylate carrier isoform X1

    2. XM_011537288.4XP_011535590.1  mitochondrial 2-oxodicarboxylate carrier isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:175268
      Mito_carr; Mitochondrial carrier protein
    3. XM_011537289.4XP_011535591.1  mitochondrial 2-oxodicarboxylate carrier isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:173266
      Mito_carr; Mitochondrial carrier protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      30867261..31362039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376909.1XP_054232884.1  mitochondrial 2-oxodicarboxylate carrier isoform X1

    2. XM_054376910.1XP_054232885.1  mitochondrial 2-oxodicarboxylate carrier isoform X2

    3. XM_054376911.1XP_054232886.1  mitochondrial 2-oxodicarboxylate carrier isoform X3