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    TRIM9 tripartite motif containing 9 [ Homo sapiens (human) ]

    Gene ID: 114088, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TRIM9provided by HGNC
    Official Full Name
    tripartite motif containing 9provided by HGNC
    Primary source
    HGNC:HGNC:16288
    See related
    Ensembl:ENSG00000100505 MIM:606555; AllianceGenome:HGNC:16288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF91; SPRING
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 15.3), gall bladder (RPKM 1.4) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM9 in Genome Data Viewer
    Location:
    14q22.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (50975266..51095105, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (45181679..45446640, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (51441984..51561823, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903314 Neighboring gene PYGL intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5734 Neighboring gene glycogen phosphorylase L Neighboring gene Sharpr-MPRA regulatory region 6562 Neighboring gene uncharacterized LOC400212 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:51452525-51453231 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:51495109-51496308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8371 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:51706801-51707143 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8373 Neighboring gene thioredoxin related transmembrane protein 1 Neighboring gene uncharacterized LOC124903315

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A new SPRING in lipid metabolism. Hendrix S, et al. Curr Opin Lipidol, 2023 Oct 1. PMID 37548386
    2. TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway. Yang F, et al. Life Sci, 2020 Sep 15. PMID 32679146
    3. Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Wang Z, et al. Ann Clin Lab Sci, 2023 Jan. PMID 36889762
    4. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Zeng J, et al. Cell Rep, 2019 Apr 9. PMID 30970257, Free PMC Article
    5. Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression. Liu K, et al. Cell Rep, 2018 Apr 17. PMID 29669288

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new SPRING in lipid metabolism.
      Title: A new SPRING in lipid metabolism.
    2. TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway.
      Title: TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway.
    3. Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
      Title: Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
    4. Knockdown of TRIM9 attenuates irinotecaninduced intestinal mucositis in IEC6 cells by regulating DUSP6 expression via the P38 pathway.
      Title: Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway.
    5. TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-kappaB signaling pathway.
      Title: TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway.
    6. Findings reveal that TRIM9 is essential for resolving NF-kappaB-dependent neuroinflammation to promote recovery and repair after brain injury.
      Title: TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.
    7. TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine. MKK6 could also stabilize TRIM9s by promoting the phosphorylation of TRIM9s at Ser76/80 via p38, thereby blocking the ubiquitin-proteasome pathway.
      Title: Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression.
    8. TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.
      Title: TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1.
    9. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK.
      Title: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.
    10. TRIM9 is a brain-specific negative regulator of the NF-kappaB pro-inflammatory signalling pathway.
      Title: Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of atypical psychosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0282

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM9
    Names
    RING finger protein 91
    RING-type E3 ubiquitin transferase TRIM9
    SNAP-25-interacting RING finger protein
    homolog of rat RING finger Spring
    tripartite motif-containing protein 9
    NP_001374289.1
    NP_001374290.1
    NP_001374291.1
    NP_001374292.1
    NP_001374293.1
    NP_001374294.1
    NP_001374295.1
    NP_001374296.1
    NP_001374297.1
    NP_001374298.1
    NP_001374299.1
    NP_001374300.1
    NP_001374301.1
    NP_001374302.1
    NP_001374303.1
    NP_001374304.1
    NP_001374305.1
    NP_001374306.1
    NP_001374307.1
    NP_001374308.1
    NP_001374309.1
    NP_055978.4
    NP_443210.1
    XP_011534691.1
    XP_016876437.1
    XP_047286861.1
    XP_054231290.1
    XP_054231291.1
    XP_054231292.1
    XP_054231293.1
    XP_054231294.1
    XP_054231295.1
    XP_054231296.1
    XP_054231297.1
    XP_054231298.1
    XP_054231299.1
    XP_054231300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387360.1 → NP_001374289.1  E3 ubiquitin-protein ligase TRIM9 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Consensus CDS
      CCDS91879.1
      UniProtKB/TrEMBL
      A0A804HIL7
      Related
      ENSP00000507131.1, ENST00000684578.1
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:620 → 785
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    2. NM_001387361.1 → NP_001374290.1  E3 ubiquitin-protein ligase TRIM9 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:449 → 528
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:616 → 781
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    3. NM_001387362.1 → NP_001374291.1  E3 ubiquitin-protein ligase TRIM9 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:612 → 777
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    4. NM_001387363.1 → NP_001374292.1  E3 ubiquitin-protein ligase TRIM9 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:608 → 773
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    5. NM_001387364.1 → NP_001374293.1  E3 ubiquitin-protein ligase TRIM9 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:606 → 771
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    6. NM_001387365.1 → NP_001374294.1  E3 ubiquitin-protein ligase TRIM9 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:620 → 767
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    7. NM_001387366.1 → NP_001374295.1  E3 ubiquitin-protein ligase TRIM9 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:596 → 763
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    8. NM_001387367.1 → NP_001374296.1  E3 ubiquitin-protein ligase TRIM9 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:449 → 528
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:592 → 759
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    9. NM_001387368.1 → NP_001374297.1  E3 ubiquitin-protein ligase TRIM9 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:557 → 722
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    10. NM_001387369.1 → NP_001374298.1  E3 ubiquitin-protein ligase TRIM9 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:271 → 326
      BBC; B-Box C-terminal domain
      cd00063
      Location:380 → 459
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:547 → 712
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    11. NM_001387370.1 → NP_001374299.1  E3 ubiquitin-protein ligase TRIM9 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:529 → 708
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    12. NM_001387371.1 → NP_001374300.1  E3 ubiquitin-protein ligase TRIM9 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 398
      BBC; B-Box C-terminal domain
      cd00063
      Location:452 → 531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:528 → 699
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    13. NM_001387372.1 → NP_001374301.1  E3 ubiquitin-protein ligase TRIM9 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:449 → 528
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:525 → 696
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    14. NM_001387373.1 → NP_001374302.1  E3 ubiquitin-protein ligase TRIM9 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:529 → 682
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    15. NM_001387374.1 → NP_001374303.1  E3 ubiquitin-protein ligase TRIM9 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (6) summary
      smart00502
      Location:271 → 326
      BBC; B-Box C-terminal domain
      cd00063
      Location:380 → 459
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12889
      Location:456 → 609
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    16. NM_001387375.1 → NP_001374304.1  E3 ubiquitin-protein ligase TRIM9 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd12889
      Location:434 → 601
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    17. NM_001387376.1 → NP_001374305.1  E3 ubiquitin-protein ligase TRIM9 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd12889
      Location:434 → 583
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    18. NM_001387377.1 → NP_001374306.1  E3 ubiquitin-protein ligase TRIM9 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      cd00063
      Location:449 → 528
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:10 → 49
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:223 → 271
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:5 → 52
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    19. NM_001387378.1 → NP_001374307.1  E3 ubiquitin-protein ligase TRIM9 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:271 → 326
      BBC; B-Box C-terminal domain
      cd12889
      Location:361 → 528
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cd16755
      Location:5 → 52
      RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19826
      Location:223 → 271
      Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
      cd19843
      Location:166 → 212
      Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

    20. NM_001387379.1 → NP_001374308.1  E3 ubiquitin-protein ligase TRIM9 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:273 → 362
      BBC; B-Box C-terminal domain
      cd00063
      Location:416 → 495
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:10 → 49
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:223 → 271
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:5 → 52
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    21. NM_001387380.1 → NP_001374309.1  E3 ubiquitin-protein ligase TRIM9 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Conserved Domains (5) summary
      smart00502
      Location:271 → 326
      BBC; B-Box C-terminal domain
      cd00063
      Location:380 → 459
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:10 → 49
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:223 → 271
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:5 → 52
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    22. NM_015163.6 → NP_055978.4  E3 ubiquitin-protein ligase TRIM9 isoform 1

      See identical proteins and their annotated locations for NP_055978.4

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Consensus CDS
      CCDS9703.1
      UniProtKB/Swiss-Prot
      D3DSB7, D3DSB8, Q92557, Q96D24, Q96NI4, Q9C025, Q9C026, Q9C027
      Related
      ENSP00000298355.3, ENST00000298355.7
      Conserved Domains (5) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      smart00336
      Location:224 → 266
      BBOX; B-Box-type zinc finger
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:9 → 38
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12889
      Location:529 → 700
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

    23. NM_052978.5 → NP_443210.1  E3 ubiquitin-protein ligase TRIM9 isoform 2

      See identical proteins and their annotated locations for NP_443210.1

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770
      Consensus CDS
      CCDS45105.1
      UniProtKB/Swiss-Prot
      Q9C026
      Related
      ENSP00000353561.4, ENST00000360392.4
      Conserved Domains (4) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      smart00336
      Location:224 → 266
      BBOX; B-Box-type zinc finger
      cd00063
      Location:453 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl17238
      Location:5 → 52
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_170640.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    2. NR_170641.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    3. NR_170642.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    4. NR_170643.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    5. NR_170644.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    6. NR_170645.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    7. NR_170646.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    8. NR_170647.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    9. NR_170648.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    10. NR_170649.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    11. NR_170650.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    12. NR_170651.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    13. NR_170652.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358334, AL591770

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      50975266..51095105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020948.2 → XP_016876437.1  E3 ubiquitin-protein ligase TRIM9 isoform X2

    2. XM_011536389.3 → XP_011534691.1  E3 ubiquitin-protein ligase TRIM9 isoform X1

      UniProtKB/Swiss-Prot
      Q9C026
      Related
      ENSP00000342970.5, ENST00000338969.9
      Conserved Domains (5) summary
      smart00502
      Location:273 → 399
      BBC; B-Box C-terminal domain
      smart00336
      Location:224 → 266
      BBOX; B-Box-type zinc finger
      cd00063
      Location:449 → 528
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:9 → 38
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12889
      Location:616 → 773
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

    3. XM_047430905.1 → XP_047286861.1  E3 ubiquitin-protein ligase TRIM9 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      45181679..45446640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375319.1 → XP_054231294.1  E3 ubiquitin-protein ligase TRIM9 isoform X7

      UniProtKB/Swiss-Prot
      D3DSB7, D3DSB8, Q92557, Q96D24, Q96NI4, Q9C025, Q9C026, Q9C027

    2. XM_054375324.1 → XP_054231299.1  E3 ubiquitin-protein ligase TRIM9 isoform X11

    3. XM_054375323.1 → XP_054231298.1  E3 ubiquitin-protein ligase TRIM9 isoform X10

    4. XM_054375322.1 → XP_054231297.1  E3 ubiquitin-protein ligase TRIM9 isoform X2

    5. XM_054375320.1 → XP_054231295.1  E3 ubiquitin-protein ligase TRIM9 isoform X8

    6. XM_054375317.1 → XP_054231292.1  E3 ubiquitin-protein ligase TRIM9 isoform X5

    7. XM_054375321.1 → XP_054231296.1  E3 ubiquitin-protein ligase TRIM9 isoform X9

    8. XM_054375318.1 → XP_054231293.1  E3 ubiquitin-protein ligase TRIM9 isoform X6

    9. XM_054375316.1 → XP_054231291.1  E3 ubiquitin-protein ligase TRIM9 isoform X4

      UniProtKB/TrEMBL
      A0A804HIL7

    10. XM_054375315.1 → XP_054231290.1  E3 ubiquitin-protein ligase TRIM9 isoform X1

    11. XM_054375325.1 → XP_054231300.1  E3 ubiquitin-protein ligase TRIM9 isoform X12

    RNA

    1. XR_008488818.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C026.1 GenPept UniProtKB/Swiss-Prot:Q9C026

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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