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Envelope surface glycoprotein gp120
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env
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Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 1 (SRSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Gag-Pol
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gag-pol
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Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 1 (SRSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Nef
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nef
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Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 1 (SRSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Pr55(Gag)
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gag
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Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 1 (SRSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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gag
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ASF/SF2 binds to the cis enhancing sequence (CES) in the gp41 region and enhances Gag expression |
PubMed
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Rev
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rev
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SF2/ASF has been shown to inhibit Rev function in a dose-dependent fashion |
PubMed
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rev
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interaction of Rev with SF2/ASF is apparently mediated by complement component 1, q subcomponent binding protein (C1QBP, p32) which associates with SF2/ASF and binds to Rev |
PubMed
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rev
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SF2/ASF binds to RRE RNA in a Rev-dependent manner, an interaction that is associated with Rev inhibition of HIV-1 mRNA splicing |
PubMed
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rev
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SF2/ASF and SRp40 interact with a purine-rich motif within the HIV-1 exon 5, and this interaction activates splicing at an upstream 3' splice site and binding of the 5' splice site to U1 snRNP, which are required for splicing of HIV-1 rev and nef mRNAs |
PubMed
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Tat
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tat
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Serine/arginine-rich splicing factor 1 (SRSF1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS |
PubMed
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tat
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HIV-1 Tat competes with SRSF1 for binding to overlapping sequences within TAR and 7SK RNA |
PubMed
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tat
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SRSF1 (serine/arginine-rich splicing factor 1) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells, which is dependent on the HIV-1 LTR promoter and the SRSF1 RNA recognition motifs |
PubMed
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tat
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HIV-1 Tat mediated splicing is regulated by activating the SF2-dependent GAR enhancer rather than repressing usage of the upstream ESE/ESS2 element |
PubMed
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tat
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HIV-1 Tat synergizes with type I activators, such as Sp1 and CTF, to enhance transcript elongation and exon skipping, suggesting Tat function leads to the inhibition of splicing factors SF2/ASF and 9G8 |
PubMed
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