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    ZNF69 zinc finger protein 69 [ Homo sapiens (human) ]

    Gene ID: 7620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZNF69provided by HGNC
    Official Full Name
    zinc finger protein 69provided by HGNC
    Primary source
    HGNC:HGNC:13138
    See related
    Ensembl:ENSG00000198429 MIM:194543; AllianceGenome:HGNC:13138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cos5; hZNF3
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 1.9), colon (RPKM 1.9) and 25 other tissues See more
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    Genomic context

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    See ZNF69 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11887782..11980222)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12015990..12108415)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11998597..12025371)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 439 Neighboring gene Sharpr-MPRA regulatory region 10901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14036 Neighboring gene vomeronasal 2 receptor 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14037 Neighboring gene zinc finger protein 440-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12033828-12034618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12034619-12035408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12035565-12036137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10135 Neighboring gene vomeronasal 2 receptor 15 pseudogene Neighboring gene zinc finger protein 700 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12060504-12060733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene zinc finger protein 763 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12098284-12099226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12099227-12100168 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Aubry M, et al. Genomics, 1992 Jul. PMID 1639391
    2. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Yeow ZY, et al. Nature, 2020 Sep. PMID 32908313, Free PMC Article
    3. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    4. CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. Lim SH, et al. Mol Syst Biol, 2022 Feb. PMID 35156780, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 69
    Names
    ZNF3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321163.2 → NP_001308092.1  zinc finger protein 69 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008770, AW132096, BG393583, BG429615
      UniProtKB/TrEMBL
      C9JR48
      Conserved Domains (2) summary
      smart00349
      Location:24 → 64
      KRAB; krueppel associated box
      pfam01352
      Location:24 → 63
      KRAB; KRAB box

    2. NM_001364730.1 → NP_001351659.1  zinc finger protein 69 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008770, BG393583, DA647393
      Consensus CDS
      CCDS92521.1
      UniProtKB/Swiss-Prot
      Q86VA7, Q9UC07
      Related
      ENSP00000402985.2, ENST00000429654.7
      Conserved Domains (3) summary
      COG5048
      Location:219 → 537
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 64
      KRAB; KRAB box

    3. NM_001364731.1 → NP_001351660.1  zinc finger protein 69 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008770, DA633065
      Conserved Domains (3) summary
      COG5048
      Location:205 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:348 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:22 → 50
      KRAB; KRAB box

    4. NM_021915.4 → NP_068734.1  zinc finger protein 69 isoform 2

      See identical proteins and their annotated locations for NP_068734.1

      Status: VALIDATED

      Source sequence(s)
      AC008770, AW132096, BC051309, BG393583
      Consensus CDS
      CCDS32914.1
      UniProtKB/TrEMBL
      C9JR48
      Related
      ENSP00000345333.5, ENST00000340180.5
      Conserved Domains (1) summary
      pfam01352
      Location:22 → 50
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11887782..11980222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027231.2 → XP_016882720.1  zinc finger protein 69 isoform X4

      UniProtKB/TrEMBL
      C9JR48
      Conserved Domains (2) summary
      smart00349
      Location:27 → 67
      KRAB; krueppel associated box
      pfam01352
      Location:27 → 66
      KRAB; KRAB box

    2. XM_006722874.4 → XP_006722937.1  zinc finger protein 69 isoform X3

      See identical proteins and their annotated locations for XP_006722937.1

      UniProtKB/TrEMBL
      C9JR48
      Conserved Domains (2) summary
      smart00349
      Location:27 → 67
      KRAB; krueppel associated box
      pfam01352
      Location:27 → 66
      KRAB; KRAB box

    3. XM_006722873.5 → XP_006722936.1  zinc finger protein 69 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:27 → 67
      KRAB; krueppel associated box
      COG5048
      Location:222 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:405 → 430
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047439351.1 → XP_047295307.1  zinc finger protein 69 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12015990..12108415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321985.1 → XP_054177960.1  zinc finger protein 69 isoform X4

      UniProtKB/TrEMBL
      C9JR48

    2. XM_054321984.1 → XP_054177959.1  zinc finger protein 69 isoform X3

      UniProtKB/TrEMBL
      C9JR48

    3. XM_054321983.1 → XP_054177958.1  zinc finger protein 69 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UC07.2 GenPept UniProtKB/Swiss-Prot:Q9UC07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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