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    ZNF121 zinc finger protein 121 [ Homo sapiens (human) ]

    Gene ID: 7675, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF121provided by HGNC
    Official Full Name
    zinc finger protein 121provided by HGNC
    Primary source
    HGNC:HGNC:12904
    See related
    Ensembl:ENSG00000197961 MIM:194628; AllianceGenome:HGNC:12904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZHC32; ZNF20; D19S204
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 3.6), spleen (RPKM 3.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF121 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9560329..9584504, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9686517..9710677, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9671005..9695180, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 426 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9648627-9649362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13931 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:9650343-9651542 Neighboring gene ZNF426 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr19:9677059-9677560 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9692318-9693131 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9693132-9693944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9694759-9695570 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9700111-9700757 Neighboring gene uncharacterized LOC105376914 Neighboring gene zinc finger protein 561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9731087-9731669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13932

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. Chen H, et al. Genomics, 1993 Mar. PMID 8468057
    2. Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. Luo A, et al. J Genet Genomics, 2016 Dec 20. PMID 27988300
    3. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. Liu W, et al. Biochem Biophys Res Commun, 2018 Jun 12. PMID 29698681
    4. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Ohira M, et al. Oncogene, 2003 Aug 21. PMID 12934113
    5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.
      Title: Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.
    2. ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation
      Title: Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 121
    Names
    zinc finger protein 121 (clone ZHC32)
    zinc finger protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008727.5 → NP_001008727.1  zinc finger protein 121

      See identical proteins and their annotated locations for NP_001008727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region resulting in use of an alternate start codon compared to variant 1. Variants 1 and 2 encode the same protein sequence.
      Source sequence(s)
      AC008567, AC008759, AU253046
      Consensus CDS
      CCDS32902.1
      UniProtKB/Swiss-Prot
      P58317
      Related
      ENSP00000326967.5, ENST00000320451.7
      Conserved Domains (4) summary
      COG5048
      Location:226 → 388
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:144 → 166
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:158 → 182
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001308269.3 → NP_001295198.1  zinc finger protein 121

      See identical proteins and their annotated locations for NP_001295198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein sequence.
      Source sequence(s)
      AA096354, AC008567, AW949690, BF763738, CN360954, CN360955, DC424100
      Consensus CDS
      CCDS77228.1
      UniProtKB/Swiss-Prot
      P58317
      Related
      ENSP00000468643.1, ENST00000586602.5
      Conserved Domains (4) summary
      COG5048
      Location:226 → 388
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:144 → 166
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:158 → 182
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9560329..9584504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027239.2 → XP_016882728.1  zinc finger protein 121 isoform X1

      UniProtKB/Swiss-Prot
      P58317
      Conserved Domains (4) summary
      COG5048
      Location:226 → 388
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:144 → 166
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:158 → 182
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9686517..9710677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322001.1 → XP_054177976.1  zinc finger protein 121 isoform X1

      UniProtKB/Swiss-Prot
      P58317
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58317.2 GenPept UniProtKB/Swiss-Prot:P58317

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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