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    ZNF850 zinc finger protein 850 [ Homo sapiens (human) ]

    Gene ID: 342892, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF850provided by HGNC
    Official Full Name
    zinc finger protein 850provided by HGNC
    Primary source
    HGNC:HGNC:27994
    See related
    Ensembl:ENSG00000267041 AllianceGenome:HGNC:27994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF850P
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 1.4), placenta (RPKM 0.7) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF850 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36743480..36772807, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39418764..39448090, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37234382..37263709, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14530 Neighboring gene zinc finger protein 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37178931-37179570 Neighboring gene ZNF567 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14533 Neighboring gene Sharpr-MPRA regulatory region 9870 Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    2. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Liu X, et al. Nat Commun, 2018 Mar 22. PMID 29568061, Free PMC Article
    5. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 850
    Names
    putative zinc finger protein ENSP00000330994

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193552.2 → NP_001180481.1  zinc finger protein 850 isoform 1

      See identical proteins and their annotated locations for NP_001180481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC020928, AC074138, BC052603
      Consensus CDS
      CCDS59379.1
      UniProtKB/Swiss-Prot
      A8MQ14
      Related
      ENSP00000464976.1, ENST00000591344.2
      Conserved Domains (5) summary
      smart00349
      Location:7 → 67
      KRAB; krueppel associated box
      COG5048
      Location:531 → 947
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:899 → 919
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:687 → 711
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001267779.2 → NP_001254708.1  zinc finger protein 850 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC020928, AC074138, AW440392, BC052603, BC143637
      Consensus CDS
      CCDS74350.1
      UniProtKB/TrEMBL
      A0A087X0M6
      Related
      ENSP00000483509.1, ENST00000614887.4
      Conserved Domains (5) summary
      smart00349
      Location:7 → 50
      KRAB; krueppel associated box
      COG5048
      Location:499 → 915
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:867 → 887
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:655 → 679
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36743480..36772807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39418764..39448090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_008207.3: Suppressed sequence

      Description
      NG_008207.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MQ14.2 GenPept UniProtKB/Swiss-Prot:A8MQ14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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