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    CEACAM8 CEA cell adhesion molecule 8 [ Homo sapiens (human) ]

    Gene ID: 1088, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CEACAM8provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 8provided by HGNC
    Primary source
    HGNC:HGNC:1820
    See related
    Ensembl:ENSG00000124469 MIM:615747; AllianceGenome:HGNC:1820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD67; CGM6; CD66b; NCA-95
    Summary
    Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward bone marrow (RPKM 58.6) See more
    Orthologs
    all
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    Genomic context

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    See CEACAM8 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42580243..42594924, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45399652..45414338, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43084395..43099076, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene uncharacterized LOC105372407 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:43032933-43033795 Neighboring gene MPRA-validated peak3492 silencer Neighboring gene MPRA-validated peak3493 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43064131-43064631 Neighboring gene CEA cell adhesion molecule pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43100409-43100909 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:43132188-43133387 Neighboring gene CEA cell adhesion molecule pseudogene 1 Neighboring gene CEA cell adhesion molecule pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer. Kovaleva OV, et al. Bull Exp Biol Med, 2023 Apr. PMID 37162631
    2. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. Zhao L, et al. J Immunol Methods, 2002 Dec 1. PMID 12379336
    3. CD66b regulates adhesion and activation of human eosinophils. Yoon J, et al. J Immunol, 2007 Dec 15. PMID 18056392
    4. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. Torsteinsdóttir I, et al. Scand J Immunol, 1999 Oct. PMID 10520185
    5. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Eades-Perner AM, et al. Blood, 1998 Jan 15. PMID 9427723

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer.
      Title: Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer.
    2. CD66b(+) monocytes represent a proinflammatory myeloid subpopulation in cancer.
      Title: CD66b(+) monocytes represent a proinflammatory myeloid subpopulation in cancer.
    3. High CEACAM8 expression is associated with metastases in breast carcinoma.
      Title: Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells.
    4. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis.
      Title: Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.
    5. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
      Title: A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.
    6. Inhibition of C5aR1 leads to a significant reduction of CD66b and CD11b expression indicating a lower neutrophil activation status and block of granule exocytosis.
      Title: CD66b Overexpression and Loss of C5a Receptors as Surface Markers for Staphylococcus aureus-Induced Neutrophil Dysfunction.
    7. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another.
      Title: Diverse oligomeric states of CEACAM IgV domains.
    8. CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses
      Title: Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
    9. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls.
      Title: Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes.
    10. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation.
      Title: High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 8
    Names
    CD67 antigen
    carcinoembryonic antigen CGM6
    carcinoembryonic antigen gene family member 6
    carcinoembryonic antigen related cell adhesion molecule 8
    non-specific cross-reacting antigen NCA-95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001816.4 → NP_001807.2  carcinoembryonic antigen-related cell adhesion molecule 8 precursor

      See identical proteins and their annotated locations for NP_001807.2

      Status: VALIDATED

      Source sequence(s)
      AK297012, BC026263, DA464901
      Consensus CDS
      CCDS12610.1
      UniProtKB/Swiss-Prot
      O60399, P31997, Q16574
      UniProtKB/TrEMBL
      Q0Z7S6
      Related
      ENSP00000244336.5, ENST00000244336.10
      Conserved Domains (3) summary
      pfam13895
      Location:239 → 307
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42580243..42594924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026195.2 → XP_016881684.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X3

      UniProtKB/Swiss-Prot
      O60399, P31997, Q16574
      UniProtKB/TrEMBL
      Q0Z7S6
      Conserved Domains (3) summary
      pfam13895
      Location:239 → 307
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    2. XM_011526341.2 → XP_011524643.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

      See identical proteins and their annotated locations for XP_011524643.1

      Conserved Domains (3) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    3. XM_047438091.1 → XP_047294047.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X2

    4. XM_017026197.3 → XP_016881686.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X4

    5. XM_011526340.3 → XP_011524642.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X1

      Conserved Domains (4) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 312
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    6. XM_011526342.2 → XP_011524644.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

      See identical proteins and their annotated locations for XP_011524644.1

      Conserved Domains (3) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    RNA

    1. XR_007066548.1 RNA Sequence

    2. XR_007066546.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45399652..45414338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319599.1 → XP_054175574.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

    2. XM_054319597.1 → XP_054175572.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X2

    3. XM_054319596.1 → XP_054175571.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X1

    4. XM_054319598.1 → XP_054175573.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X4

    5. XM_054319600.1 → XP_054175575.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

    RNA

    1. XR_008485070.1 RNA Sequence

    2. XR_008485069.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31997.2 GenPept UniProtKB/Swiss-Prot:P31997

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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