LIN28A lin-28 homolog A [Homo sapiens (human)] - Gene

Summary

Official Symbol: LIN28Aprovided by HGNC
Official Full Name: lin-28 homolog Aprovided by HGNC
Primary source: HGNC:HGNC:15986
See related: Ensembl:ENSG00000131914 MIM:611043; AllianceGenome:HGNC:15986
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A
Summary: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
Expression: Restricted expression toward testis (RPKM 1.6) See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (26410817..26429728)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (26248852..26267747)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (26737308..26756219)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway.
Title: MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-β1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway.
Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis.
Title: Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis.
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Title: Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-kappaB/NLRP3 inflammasome pathway.
Title: GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway.
Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.
Title: Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.
Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.
Title: Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.
Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.
Title: Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.
Title: Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.
Lin28 promoting the protective effect of PMSCs on hepatic ischaemia-reperfusion injury by regulating glucose metabolism.
Title: Lin28 promoting the protective effect of PMSCs on hepatic ischaemia-reperfusion injury by regulating glucose metabolism.
Analysis of LIN28A variants in patients with Parkinson's disease.
Title: Analysis of LIN28A variants in patients with Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (156)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z94399 (e-PCR)
- UniSTS:43808

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D13S1553 (e-PCR)
- UniSTS:473482

D11S3114 (e-PCR)
- UniSTS:152207

RH66756 (e-PCR)
- UniSTS:89576

D11S1085 (e-PCR)
- UniSTS:4587

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IEA Inferred from Electronic Annotation more info
involved_in RNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell proliferation involved in kidney development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleolus	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein lin-28 homolog A

Names: RNA-binding protein LIN-28; zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024674.6 → NP_078950.1 protein lin-28 homolog A

See identical proteins and their annotated locations for NP_078950.1

Status: REVIEWED

Source sequence(s)

AL513365, BC028566

Consensus CDS

CCDS280.1

UniProtKB/Swiss-Prot

Q9H9Z2

Related

ENSP00000363314.3, ENST00000326279.11

Conserved Domains (2) summary

pfam00313
Location:42 → 112

CSD; 'Cold-shock' DNA-binding domain

cl26705
Location:120 → 183

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

26410817..26429728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542148.3 → XP_011540450.1 protein lin-28 homolog A isoform X1

See identical proteins and their annotated locations for XP_011540450.1

UniProtKB/Swiss-Prot

Q9H9Z2

Conserved Domains (2) summary

pfam00313
Location:42 → 112

CSD; 'Cold-shock' DNA-binding domain

cl26705
Location:120 → 183

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]