HRH3 histamine receptor H3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HRH3provided by HGNC
Official Full Name: histamine receptor H3provided by HGNC
Primary source: HGNC:HGNC:5184
See related: Ensembl:ENSG00000101180 MIM:604525; AllianceGenome:HGNC:5184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HH3R; GPCR97
Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 2.9), testis (RPKM 0.2) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (62214960..62220278, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (64006090..64011408, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (60790016..60795334, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection.
Title: Recovery of the histamine H(3) receptor activity lost in yeast cells through error-prone PCR and in vivo selection.
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
Title: Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder.
Title: Histamine H(3) receptor gene variants associated with drug abuse in patients with cocaine use disorder.
Histamine, histamine H3 receptor, and alcohol use disorder.
Title: Histamine, histamine H(3) receptor, and alcohol use disorder.
These findings revealed that HRH3 serves an important role in the growth and metastasis of hepatocellular carcinomacells, which provides experimental evidence supporting the application of HRH3 as a potential therapeutic target in hepatocellular carcinoma treatment
Title: Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma.
These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation.
Title: Differential expression and signaling of the human histamine H(3) receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells.
results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor
Title: The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H(3) receptor.
We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis.
Title: Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.
These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population
Title: Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy.
Title: Pharmacoresistant temporal lobe epilepsy modifies histamine turnover and H3 receptor function in the human hippocampus and temporal neocortex.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histamine H3 receptor

Names: G protein-coupled receptor 97; H3R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007232.3 → NP_009163.2 histamine H3 receptor

See identical proteins and their annotated locations for NP_009163.2

Status: VALIDATED

Source sequence(s)

AL078633

Consensus CDS

CCDS13493.1

UniProtKB/Swiss-Prot

Q4QRI7, Q9GZX2, Q9H4K8, Q9Y5N1

UniProtKB/TrEMBL

Q548M6

Related

ENSP00000342560.5, ENST00000340177.10

Conserved Domains (1) summary

pfam00001
Location:51 → 412

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

62214960..62220278 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017027623.2 → XP_016883112.2 histamine H3 receptor isoform X2

UniProtKB/TrEMBL

Q548M6
XM_005260266.4 → XP_005260323.1 histamine H3 receptor isoform X1

See identical proteins and their annotated locations for XP_005260323.1

UniProtKB/TrEMBL

Q548M6

Related

ENSP00000321482.7, ENST00000317393.10

Conserved Domains (1) summary

pfam00001
Location:51 → 412

7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

64006090..64011408 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322917.1 → XP_054178892.1 histamine H3 receptor isoform X2

UniProtKB/TrEMBL

Q548M6
XM_054322916.1 → XP_054178891.1 histamine H3 receptor isoform X1

UniProtKB/TrEMBL

Q548M6