ODF2 outer dense fiber of sperm tails 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ODF2provided by HGNC
Official Full Name: outer dense fiber of sperm tails 2provided by HGNC
Primary source: HGNC:HGNC:8114
See related: Ensembl:ENSG00000136811 MIM:602015; AllianceGenome:HGNC:8114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT134; ODF84; ODF2/1; ODF2/2
Summary: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Expression: Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q34.11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (128455185..128501292)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (140662221..140708139)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (131217464..131263571)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sperm DNA fragmentation and apoptosis in the sperm of men with oligozoospermia are closely related to anti-ODF2 autoantibodies.
Title: Sperm DNA fragmentation and apoptosis in the sperm of men with oligozoospermia are closely related to anti-ODF2 autoantibodies.
Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1.
Title: Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1.
alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.
Title: MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.
C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
Title: C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
Odf2 interacts with Cep128 to form the subdistal appendage of the centriole.
Title: Cep128 associates with Odf2 to form the subdistal appendage of the centriole.
Cenexin controls centrosome positioning during cell migration by modulating microtubule organization and stability.Cenexin is required for spindle orientation.
Title: The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation.
Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx.
Title: A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation.
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Title: Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation.
Title: Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Odf2 (e-PCR), detects polymorphism
- UniSTS:515334

Odf2 (e-PCR), detects polymorphism
- UniSTS:515335

STS-AA034010 (e-PCR)
- UniSTS:71699

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of centriolar subdistal appendage	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm principal piece	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: outer dense fiber protein 2

Names: cancer/testis antigen 134; cenexin 1; outer dense fiber of sperm tails, 84-kD; sperm tail structural protein; testis tissue sperm-binding protein Li 51e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029568.2 RefSeqGene

Range

5823..51109

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242352.2 → NP_001229281.1 outer dense fiber protein 2 isoform 11

See identical proteins and their annotated locations for NP_001229281.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses two alternate splice sites in the 5' coding region, compared to variant 1. The resulting isoform (11) has a shorter N-terminus and contains an additional internal segment compared to isoform 1.

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56590.1

UniProtKB/Swiss-Prot

Q5BJF6

Related

ENSP00000361893.5, ENST00000372807.10

Conserved Domains (1) summary

cl25732
Location:114 → 798

SMC_N; RecF/RecN/SMC N terminal domain
NM_001242353.2 → NP_001229282.1 outer dense fiber protein 2 isoform 2

See identical proteins and their annotated locations for NP_001229282.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) contains an alternate exon, lacks an exon and uses an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56588.1

UniProtKB/Swiss-Prot

B1AND3, B4DRK4, B4DX73, B4DZ02, E7EWL2, F5H6J4, O14721, O60631, Q1W2J6, Q5BJF6, Q6UN26, Q7Z5I6, Q96FN2

Related

ENSP00000473949.2, ENST00000604420.5

Conserved Domains (1) summary

COG1196
Location:119 → 803

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001242354.2 → NP_001229283.1 outer dense fiber protein 2 isoform 8

See identical proteins and their annotated locations for NP_001229283.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate splice site in the 5' coding region, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (8) is shorter at the N-terminus, lacks an alternate internal segment, and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56589.1

UniProtKB/TrEMBL

B4DUU0

Related

ENSP00000396687.2, ENST00000448249.8

Conserved Domains (1) summary

cl25732
Location:165 → 485

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351577.1 → NP_001338506.1 outer dense fiber protein 2 isoform 12

Status: REVIEWED

Source sequence(s)

AI478559, AL043836, AL445287, BE263555, BM824222, BQ896996, CN368207, DB094573, DC295950, HY281035

Conserved Domains (1) summary

cl25732
Location:202 → 930

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351578.2 → NP_001338507.1 outer dense fiber protein 2 isoform 13

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS94498.1

UniProtKB/TrEMBL

A0A8J8YVX4

Related

ENSP00000342581.4, ENST00000351030.8

Conserved Domains (1) summary

cl25732
Location:202 → 886

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351579.2 → NP_001338508.1 outer dense fiber protein 2 isoform 14

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

cl25732
Location:241 → 561

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351580.2 → NP_001338509.1 outer dense fiber protein 2 isoform 14

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

cl25732
Location:241 → 561

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351581.1 → NP_001338510.1 outer dense fiber protein 2 isoform 15

Status: REVIEWED

Source sequence(s)

AI478559, AK299303, AL445287, DB094573

Conserved Domains (1) summary

cl25732
Location:163 → 847

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351582.2 → NP_001338511.1 outer dense fiber protein 2 isoform 16

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

COG1196
Location:158 → 842

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001351583.2 → NP_001338512.1 outer dense fiber protein 2 isoform 17

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

cl25732
Location:222 → 542

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351584.2 → NP_001338513.1 outer dense fiber protein 2 isoform 11

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56590.1

Conserved Domains (1) summary

cl25732
Location:114 → 798

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351585.2 → NP_001338514.1 outer dense fiber protein 2 isoform 11

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56590.1

Conserved Domains (1) summary

cl25732
Location:114 → 798

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351586.2 → NP_001338515.1 outer dense fiber protein 2 isoform 9

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

UniProtKB/TrEMBL

A0A024R8A5

Conserved Domains (1) summary

COG1196
Location:95 → 779

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001351587.2 → NP_001338516.1 outer dense fiber protein 2 isoform 18

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

cl25732
Location:111 → 745

SMC_N; RecF/RecN/SMC N terminal domain
NM_001351588.2 → NP_001338517.1 outer dense fiber protein 2 isoform 19

Status: REVIEWED

Source sequence(s)

AL359091, AL445287

Conserved Domains (1) summary

cl25732
Location:92 → 726

SMC_N; RecF/RecN/SMC N terminal domain
NM_002540.5 → NP_002531.3 outer dense fiber protein 2 isoform 9

See identical proteins and their annotated locations for NP_002531.3

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains two alternate exons in the 5' coding region, compared to variant 1. The resulting isoform (9) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL359091, AL445287

UniProtKB/TrEMBL

A0A024R8A5

Conserved Domains (1) summary

COG1196
Location:95 → 779

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_153432.1 → NP_702910.1 outer dense fiber protein 2 isoform 3

See identical proteins and their annotated locations for NP_702910.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK093367, AL359091, DB094573, DB511337

Consensus CDS

CCDS56586.1

UniProtKB/TrEMBL

B4DX03

Related

ENSP00000361901.3, ENST00000372814.7

Conserved Domains (1) summary

COG1196
Location:290 → 627

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_153433.2 → NP_702911.1 outer dense fiber protein 2 isoform 2

See identical proteins and their annotated locations for NP_702911.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple 5' coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 10 both encode the same isoform (2).

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56588.1

UniProtKB/Swiss-Prot

B1AND3, B4DRK4, B4DX73, B4DZ02, E7EWL2, F5H6J4, O14721, O60631, Q1W2J6, Q5BJF6, Q6UN26, Q7Z5I6, Q96FN2

Related

ENSP00000403453.2, ENST00000434106.7

Conserved Domains (1) summary

COG1196
Location:119 → 803

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_153435.1 → NP_702913.1 outer dense fiber protein 2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL445287, AY366499, DB094573

Consensus CDS

CCDS94497.1

UniProtKB/TrEMBL

A0A8J8Z1C3

Related

ENSP00000377161.6, ENST00000393527.8

Conserved Domains (1) summary

pfam00038
Location:529 → 857

Filament; Intermediate filament protein
NM_153436.2 → NP_702914.1 outer dense fiber protein 2 isoform 4

See identical proteins and their annotated locations for NP_702914.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 4) has distinct N- and C-termini and is shorter than isoform 1.

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56585.1

UniProtKB/TrEMBL

B4DX85

Related

ENSP00000377166.2, ENST00000393533.6

Conserved Domains (2) summary

COG1196
Location:246 → 566

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:104 → 384

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_153437.3 → NP_702915.1 outer dense fiber protein 2 isoform 6

See identical proteins and their annotated locations for NP_702915.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 6) has distinct N- and C-termini and is shorter than isoform 1.

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS6902.1

UniProtKB/TrEMBL

B4DX85

Related

ENSP00000361877.3, ENST00000372791.8

Conserved Domains (2) summary

COG1196
Location:227 → 547

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:85 → 365

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_153439.1 → NP_702917.1 outer dense fiber protein 2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 3' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK301754, AL359091, DB094573, DB511337

UniProtKB/TrEMBL

B4DX03

Conserved Domains (2) summary

COG1196
Location:271 → 606

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:129 → 409

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_153440.2 → NP_702918.1 outer dense fiber protein 2 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 7) has distinct N- and C-termini and is shorter than isoform 1.

Source sequence(s)

AL359091, AL445287

Consensus CDS

CCDS56587.1

UniProtKB/TrEMBL

B4DX85

Related

ENSP00000437579.1, ENST00000546203.5

Conserved Domains (2) summary

COG1196
Location:227 → 547

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:85 → 365

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type