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    MPLKIP M-phase specific PLK1 interacting protein [ Homo sapiens (human) ]

    Gene ID: 136647, updated on 9-Dec-2024

    Summary

    Official Symbol
    MPLKIPprovided by HGNC
    Official Full Name
    M-phase specific PLK1 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16002
    See related
    Ensembl:ENSG00000168303 MIM:609188; AllianceGenome:HGNC:16002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABHS; TTD4; ORF20; C7orf11
    Summary
    The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPLKIP in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (40126027..40134622, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (40283484..40292079, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (40165626..40174221, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18115 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39989224-39990142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39991063-39991981 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:40015128-40015628 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:40017861-40018605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25889 Neighboring gene cyclin dependent kinase 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:40095303-40095542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18118 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:40186973-40188172 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:40188525-40189421 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 7 Neighboring gene THUMP domain containing 3 pseudogene 1 Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene uncharacterized LOC105375245

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    M-phase-specific PLK1-interacting protein
    Names
    Russell-Silver syndrome region
    TTD non-photosensitive 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016989.2 RefSeqGene

      Range
      5031..13626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_468

    mRNA and Protein(s)

    1. NM_138701.4NP_619646.1  M-phase-specific PLK1-interacting protein

      See identical proteins and their annotated locations for NP_619646.1

      Status: REVIEWED

      Source sequence(s)
      AC006023, BC026265, BG501110
      Consensus CDS
      CCDS5463.1
      UniProtKB/Swiss-Prot
      Q8TAP9
      UniProtKB/TrEMBL
      A4D1W6
      Related
      ENSP00000304553.5, ENST00000306984.8
      Conserved Domains (1) summary
      pfam15502
      Location:123179
      MPLKIP; M-phase-specific PLK1-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      40126027..40134622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      40283484..40292079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)