HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HUWE1provided by HGNC
Official Full Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source: HGNC:HGNC:30892
See related: Ensembl:ENSG00000086758 MIM:300697; AllianceGenome:HGNC:30892
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MULE; Ib772; LASU1; MRXST; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272
Summary: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Expression: Ubiquitous expression in ovary (RPKM 14.5), testis (RPKM 13.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.22

Exon count:: 87

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (53532096..53686719, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (52818443..52973077, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (53559057..53713664, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.
Title: The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.
The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
Title: The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARalpha pathway in Chinese individuals.
Title: A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.
A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-11q splice variant.
Title: A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Title: HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.
Title: The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.
TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
Title: TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.
Title: The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.
E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of beta-PDGFR.
Title: E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.
Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.
Title: Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, X-linked syndromic, Turner type MedGen: C2678046 OMIM: 309590 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2018-09-26) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2018-09-26) ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Gag-Pol	gag-pol	Co-immunoprecipitation shows interaction of HIV-1 Gag-Pol with Huwe1 through IN domain (residues 1148-1435)	PubMed
Rev	rev	HIV-1 Rev interacting protein, HECT, UBA and WWE domain containing 1 (HUWE1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed
Vif	vif	HIV-1 Vif is identified to have a physical interaction with HECT, UBA and WWE domain containing 1 (HUWE1) in human HEK293 and/or Jurkat cell lines	PubMed
integrase	gag-pol	Co-immunoprecipitation shows interaction of HIV-1 IN with Huwe1 through the CCD domain of IN	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) at amino acid residues 3686-3687 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-80022 (e-PCR)
- UniSTS:101638

WI-12365 (e-PCR)
- UniSTS:59920

MARC_5969-5970:991939821:1 (e-PCR)
- UniSTS:231188

MARC_5969-5970:996691406:1 (e-PCR)
- UniSTS:231188

RH11216 (e-PCR)
- UniSTS:30741

DXS8230 (e-PCR)
- UniSTS:55074

RH66308 (e-PCR)
- UniSTS:71463

MARC_15341-15342:1017678837:1 (e-PCR)
- UniSTS:267819

L77820 (e-PCR)
- UniSTS:70191

AL023608 (e-PCR)
- UniSTS:18500

MARC_6753-6754:992007394:1 (e-PCR)
- UniSTS:231261

RH65358 (e-PCR)
- UniSTS:92254

WI-19261 (e-PCR)
- UniSTS:29536

AL023918 (e-PCR)
- UniSTS:5508

RH118662 (e-PCR)
- UniSTS:138155

WI-14649 (e-PCR)
- UniSTS:40894

RH46399 (e-PCR)
- UniSTS:52723

GDB:314533 (e-PCR)
- UniSTS:20213

RH79713 (e-PCR)
- UniSTS:89847

IB772 (e-PCR)
- UniSTS:59641

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	HDA more info	PubMed
enables histone ubiquitin ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-ubiquitin ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to mitochondrion	HMP more info	PubMed
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type 2 mitophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein branched polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HUWE1

Names: ARF-binding protein 1; BJ-HCC-24 tumor antigen; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT-type E3 ubiquitin transferase HUWE1; Mcl-1 ubiquitin ligase E3; URE-binding protein 1; homologous to E6AP carboxyl terminus homologous protein 9; large structure of UREB1; upstream regulatory element-binding protein 1

NP_113584.3

EC 2.3.2.26

XP_005262022.1

EC 2.3.2.26

XP_011529049.1

EC 2.3.2.26

XP_011529053.1

EC 2.3.2.26

XP_016884687.1

EC 2.3.2.26

XP_016884688.1

EC 2.3.2.26

XP_016884691.1

EC 2.3.2.26

XP_016884692.1

EC 2.3.2.26

XP_047297667.1

EC 2.3.2.26

XP_047297668.1

EC 2.3.2.26

XP_047297669.1

EC 2.3.2.26

XP_047297670.1

EC 2.3.2.26

XP_047297671.1

EC 2.3.2.26

XP_047297672.1

EC 2.3.2.26

XP_047297673.1

EC 2.3.2.26

XP_047297674.1

EC 2.3.2.26

XP_047297675.1

EC 2.3.2.26

XP_047297676.1

EC 2.3.2.26

XP_047297677.1

EC 2.3.2.26

XP_047297678.1

EC 2.3.2.26

XP_047297679.1

EC 2.3.2.26

XP_047297680.1

EC 2.3.2.26

XP_047297681.1

EC 2.3.2.26

XP_047297682.1

EC 2.3.2.26

XP_047297683.1

EC 2.3.2.26

XP_047297684.1

EC 2.3.2.26

XP_047297685.1

EC 2.3.2.26

XP_047297686.1

EC 2.3.2.26

XP_047297687.1

EC 2.3.2.26

XP_047297688.1

EC 2.3.2.26

XP_047297689.1

EC 2.3.2.26

XP_047297690.1

EC 2.3.2.26

XP_047297691.1

EC 2.3.2.26

XP_047297692.1

EC 2.3.2.26

XP_047297693.1

EC 2.3.2.26

XP_047297694.1

EC 2.3.2.26

XP_047297695.1

EC 2.3.2.26

XP_047297696.1

EC 2.3.2.26

XP_047297697.1

EC 2.3.2.26

XP_047297698.1

EC 2.3.2.26

XP_047297699.1

EC 2.3.2.26

XP_047297700.1

EC 2.3.2.26

XP_047297701.1

EC 2.3.2.26

XP_047297702.1

EC 2.3.2.26

XP_047297703.1

EC 2.3.2.26

XP_047297704.1

EC 2.3.2.26

XP_047297705.1

EC 2.3.2.26

XP_047297706.1

EC 2.3.2.26

XP_047297707.1

EC 2.3.2.26

XP_047297708.1

EC 2.3.2.26

XP_054182256.1

EC 2.3.2.26

XP_054182257.1

EC 2.3.2.26

XP_054182258.1

EC 2.3.2.26

XP_054182259.1

EC 2.3.2.26

XP_054182260.1

EC 2.3.2.26

XP_054182261.1

EC 2.3.2.26

XP_054182262.1

EC 2.3.2.26

XP_054182263.1

EC 2.3.2.26

XP_054182264.1

EC 2.3.2.26

XP_054182265.1

EC 2.3.2.26

XP_054182266.1

EC 2.3.2.26

XP_054182267.1

EC 2.3.2.26

XP_054182268.1

EC 2.3.2.26

XP_054182269.1

EC 2.3.2.26

XP_054182270.1

EC 2.3.2.26

XP_054182271.1

EC 2.3.2.26

XP_054182272.1

EC 2.3.2.26

XP_054182273.1

EC 2.3.2.26

XP_054182274.1

EC 2.3.2.26

XP_054182275.1

EC 2.3.2.26

XP_054182276.1

EC 2.3.2.26

XP_054182277.1

EC 2.3.2.26

XP_054182278.1

EC 2.3.2.26

XP_054182279.1

EC 2.3.2.26

XP_054182280.1

EC 2.3.2.26

XP_054182281.1

EC 2.3.2.26

XP_054182282.1

EC 2.3.2.26

XP_054182283.1

EC 2.3.2.26

XP_054182284.1

EC 2.3.2.26

XP_054182285.1

EC 2.3.2.26

XP_054182286.1

EC 2.3.2.26

XP_054182287.1

EC 2.3.2.26

XP_054182288.1

EC 2.3.2.26

XP_054182289.1

EC 2.3.2.26

XP_054182290.1

EC 2.3.2.26

XP_054182291.1

EC 2.3.2.26

XP_054182292.1

EC 2.3.2.26

XP_054182293.1

EC 2.3.2.26

XP_054182294.1

EC 2.3.2.26

XP_054182295.1

EC 2.3.2.26

XP_054182296.1

EC 2.3.2.26

XP_054182297.1

EC 2.3.2.26

XP_054182298.1

EC 2.3.2.26

XP_054182299.1

EC 2.3.2.26

XP_054182300.1

EC 2.3.2.26

XP_054182301.1

EC 2.3.2.26

XP_054182302.1

EC 2.3.2.26

XP_054182303.1

EC 2.3.2.26

XP_054182304.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016261.2 RefSeqGene

Range

5015..159638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_031407.7 → NP_113584.3 E3 ubiquitin-protein ligase HUWE1

See identical proteins and their annotated locations for NP_113584.3

Status: REVIEWED

Source sequence(s)

AB002310, AC231658, AY772009, BX323845, DQ097177, R60532

Consensus CDS

CCDS35301.1

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9

UniProtKB/TrEMBL

A0A994J483

Related

ENSP00000262854.6, ENST00000262854.11

Conserved Domains (7) summary

smart00119
Location:4043 → 4371

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4019 → 4372

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd14288
Location:1317 → 1356

UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

pfam02825
Location:1617 → 1678

WWE; WWE domain

pfam06012
Location:92 → 367

DUF908; Domain of Unknown Function (DUF908)

pfam06025
Location:430 → 814

DUF913; Domain of Unknown Function (DUF913)

pfam14377
Location:2968 → 3077

DUF4414; Domain of unknown function (DUF4414)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

53532096..53686719 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441744.1 → XP_047297700.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_047441734.1 → XP_047297690.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_047441751.1 → XP_047297707.1 E3 ubiquitin-protein ligase HUWE1 isoform X25
XM_047441741.1 → XP_047297697.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_011530747.2 → XP_011529049.1 E3 ubiquitin-protein ligase HUWE1 isoform X3

See identical proteins and their annotated locations for XP_011529049.1

UniProtKB/TrEMBL

A0A994J483

Conserved Domains (7) summary

cd00078
Location:4102 → 4455

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd14288
Location:1400 → 1439

UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

pfam02825
Location:1700 → 1761

WWE; WWE domain

pfam06012
Location:92 → 367

DUF908; Domain of Unknown Function (DUF908)

pfam06025
Location:430 → 897

DUF913; Domain of Unknown Function (DUF913)

pfam14377
Location:3051 → 3160

DUF4414; Domain of unknown function (DUF4414)

cl26464
Location:2818 → 3149

Atrophin-1; Atrophin-1 family
XM_047441739.1 → XP_047297695.1 E3 ubiquitin-protein ligase HUWE1 isoform X18
XM_047441729.1 → XP_047297685.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_017029199.2 → XP_016884688.1 E3 ubiquitin-protein ligase HUWE1 isoform X1

UniProtKB/TrEMBL

A0A994J483
XM_047441736.1 → XP_047297692.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_047441742.1 → XP_047297698.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_047441732.1 → XP_047297688.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_047441713.1 → XP_047297669.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_047441730.1 → XP_047297686.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_017029202.2 → XP_016884691.1 E3 ubiquitin-protein ligase HUWE1 isoform X1

UniProtKB/TrEMBL

A0A994J483
XM_047441752.1 → XP_047297708.1 E3 ubiquitin-protein ligase HUWE1 isoform X26
XM_047441743.1 → XP_047297699.1 E3 ubiquitin-protein ligase HUWE1 isoform X20

Related

ENSP00000515693.1, ENST00000704099.1
XM_047441735.1 → XP_047297691.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_047441750.1 → XP_047297706.1 E3 ubiquitin-protein ligase HUWE1 isoform X25
XM_047441740.1 → XP_047297696.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_005261965.5 → XP_005262022.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

See identical proteins and their annotated locations for XP_005262022.1

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9

UniProtKB/TrEMBL

A0A994J483

Related

ENSP00000340648.3, ENST00000342160.7

Conserved Domains (7) summary

smart00119
Location:4043 → 4371

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4019 → 4372

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd14288
Location:1317 → 1356

UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

pfam02825
Location:1617 → 1678

WWE; WWE domain

pfam06012
Location:92 → 367

DUF908; Domain of Unknown Function (DUF908)

pfam06025
Location:430 → 814

DUF913; Domain of Unknown Function (DUF913)

pfam14377
Location:2968 → 3077

DUF4414; Domain of unknown function (DUF4414)
XM_047441714.1 → XP_047297670.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_047441738.1 → XP_047297694.1 E3 ubiquitin-protein ligase HUWE1 isoform X18
XM_047441728.1 → XP_047297684.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_047441747.1 → XP_047297703.1 E3 ubiquitin-protein ligase HUWE1 isoform X22
XM_047441727.1 → XP_047297683.1 E3 ubiquitin-protein ligase HUWE1 isoform X14
XM_047441724.1 → XP_047297680.1 E3 ubiquitin-protein ligase HUWE1 isoform X11
XM_047441722.1 → XP_047297678.1 E3 ubiquitin-protein ligase HUWE1 isoform X9
XM_047441720.1 → XP_047297676.1 E3 ubiquitin-protein ligase HUWE1 isoform X7
XM_047441718.1 → XP_047297674.1 E3 ubiquitin-protein ligase HUWE1 isoform X5
XM_047441712.1 → XP_047297668.1 E3 ubiquitin-protein ligase HUWE1 isoform X2
XM_047441749.1 → XP_047297705.1 E3 ubiquitin-protein ligase HUWE1 isoform X24
XM_047441748.1 → XP_047297704.1 E3 ubiquitin-protein ligase HUWE1 isoform X23
XM_047441746.1 → XP_047297702.1 E3 ubiquitin-protein ligase HUWE1 isoform X21
XM_047441726.1 → XP_047297682.1 E3 ubiquitin-protein ligase HUWE1 isoform X13
XM_047441725.1 → XP_047297681.1 E3 ubiquitin-protein ligase HUWE1 isoform X12
XM_047441723.1 → XP_047297679.1 E3 ubiquitin-protein ligase HUWE1 isoform X10
XM_047441721.1 → XP_047297677.1 E3 ubiquitin-protein ligase HUWE1 isoform X8
XM_047441719.1 → XP_047297675.1 E3 ubiquitin-protein ligase HUWE1 isoform X6
XM_047441717.1 → XP_047297673.1 E3 ubiquitin-protein ligase HUWE1 isoform X4
XM_017029198.3 → XP_016884687.1 E3 ubiquitin-protein ligase HUWE1 isoform X1

UniProtKB/TrEMBL

A0A994J483
XM_047441745.1 → XP_047297701.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_047441737.1 → XP_047297693.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_047441731.1 → XP_047297687.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9

Related

ENSP00000479451.1, ENST00000612484.4
XM_011530751.3 → XP_011529053.1 E3 ubiquitin-protein ligase HUWE1 isoform X3

See identical proteins and their annotated locations for XP_011529053.1

UniProtKB/TrEMBL

A0A994J483

Conserved Domains (7) summary

cd00078
Location:4102 → 4455

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd14288
Location:1400 → 1439

UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

pfam02825
Location:1700 → 1761

WWE; WWE domain

pfam06012
Location:92 → 367

DUF908; Domain of Unknown Function (DUF908)

pfam06025
Location:430 → 897

DUF913; Domain of Unknown Function (DUF913)

pfam14377
Location:3051 → 3160

DUF4414; Domain of unknown function (DUF4414)

cl26464
Location:2818 → 3149

Atrophin-1; Atrophin-1 family
XM_017029203.2 → XP_016884692.1 E3 ubiquitin-protein ligase HUWE1 isoform X1

UniProtKB/TrEMBL

A0A994J483
XM_047441733.1 → XP_047297689.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_047441715.1 → XP_047297671.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_047441711.1 → XP_047297667.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_047441716.1 → XP_047297672.1 E3 ubiquitin-protein ligase HUWE1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

52818443..52973077 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326321.1 → XP_054182296.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_054326310.1 → XP_054182285.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_054326328.1 → XP_054182303.1 E3 ubiquitin-protein ligase HUWE1 isoform X25
XM_054326318.1 → XP_054182293.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_054326287.1 → XP_054182262.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_054326316.1 → XP_054182291.1 E3 ubiquitin-protein ligase HUWE1 isoform X18
XM_054326304.1 → XP_054182279.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_054326281.1 → XP_054182256.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_054326312.1 → XP_054182287.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_054326319.1 → XP_054182294.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_054326307.1 → XP_054182282.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_054326288.1 → XP_054182263.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_054326305.1 → XP_054182280.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_054326282.1 → XP_054182257.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_054326309.1 → XP_054182284.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_054326291.1 → XP_054182266.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_054326285.1 → XP_054182260.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_054326329.1 → XP_054182304.1 E3 ubiquitin-protein ligase HUWE1 isoform X26
XM_054326320.1 → XP_054182295.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_054326311.1 → XP_054182286.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_054326327.1 → XP_054182302.1 E3 ubiquitin-protein ligase HUWE1 isoform X25
XM_054326317.1 → XP_054182292.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_054326315.1 → XP_054182290.1 E3 ubiquitin-protein ligase HUWE1 isoform X18
XM_054326303.1 → XP_054182278.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_054326324.1 → XP_054182299.1 E3 ubiquitin-protein ligase HUWE1 isoform X22
XM_054326302.1 → XP_054182277.1 E3 ubiquitin-protein ligase HUWE1 isoform X14
XM_054326299.1 → XP_054182274.1 E3 ubiquitin-protein ligase HUWE1 isoform X11
XM_054326297.1 → XP_054182272.1 E3 ubiquitin-protein ligase HUWE1 isoform X9
XM_054326295.1 → XP_054182270.1 E3 ubiquitin-protein ligase HUWE1 isoform X7
XM_054326293.1 → XP_054182268.1 E3 ubiquitin-protein ligase HUWE1 isoform X5
XM_054326286.1 → XP_054182261.1 E3 ubiquitin-protein ligase HUWE1 isoform X2
XM_054326326.1 → XP_054182301.1 E3 ubiquitin-protein ligase HUWE1 isoform X24
XM_054326325.1 → XP_054182300.1 E3 ubiquitin-protein ligase HUWE1 isoform X23
XM_054326323.1 → XP_054182298.1 E3 ubiquitin-protein ligase HUWE1 isoform X21
XM_054326301.1 → XP_054182276.1 E3 ubiquitin-protein ligase HUWE1 isoform X13
XM_054326300.1 → XP_054182275.1 E3 ubiquitin-protein ligase HUWE1 isoform X12
XM_054326298.1 → XP_054182273.1 E3 ubiquitin-protein ligase HUWE1 isoform X10
XM_054326296.1 → XP_054182271.1 E3 ubiquitin-protein ligase HUWE1 isoform X8
XM_054326294.1 → XP_054182269.1 E3 ubiquitin-protein ligase HUWE1 isoform X6
XM_054326292.1 → XP_054182267.1 E3 ubiquitin-protein ligase HUWE1 isoform X4
XM_054326322.1 → XP_054182297.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_054326314.1 → XP_054182289.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_054326306.1 → XP_054182281.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_054326289.1 → XP_054182264.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_054326308.1 → XP_054182283.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

UniProtKB/Swiss-Prot

O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
XM_054326284.1 → XP_054182259.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_054326283.1 → XP_054182258.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_054326313.1 → XP_054182288.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_054326290.1 → XP_054182265.1 E3 ubiquitin-protein ligase HUWE1 isoform X3