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    Tssk3 testis-specific serine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 58864, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tssk3provided by MGI
    Official Full Name
    testis-specific serine kinase 3provided by MGI
    Primary source
    MGI:MGI:1929914
    See related
    Ensembl:ENSMUSG00000000411 AllianceGenome:MGI:1929914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsk-3; Stk22c; Stk22d; Tssk-3; Tssk3b; 1700014N07Rik; 4930594I21Rik
    Summary
    Enables magnesium ion binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in spermatid development. Is active in sperm flagellum. Is expressed in germ cell of testis; spermatid; spermatocyte; and testis. Orthologous to human TSSK3 (testis specific serine kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward testis adult (RPKM 112.4) See more
    Orthologs
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    Genomic context

    See Tssk3 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129382801..129385523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129489008..129491730, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129138525-129138708 Neighboring gene predicted gene, 24621 Neighboring gene BSD domain containing 1 Neighboring gene family with sequence similarity 229, member A Neighboring gene STARR-positive B cell enhancer ABC_E6223 Neighboring gene STARR-seq mESC enhancer starr_11499 Neighboring gene MARCKS-like 1 Neighboring gene histone deacetylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1039

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables magnesium ion binding  
    enables manganese ion binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction PubMed 
    involved_in protein phosphorylation  
    involved_in sperm capacitation PubMed 
    involved_in spermatid development  
    involved_in spermatid development PubMed 
    involved_in spermatogenesis PubMed 
    Component Evidence Code Pubs
    is_active_in sperm flagellum PubMed 

    General protein information

    Preferred Names
    testis-specific serine/threonine-protein kinase 3
    Names
    serine/threonine kinase 22C (spermiogenesis associated)
    serine/threonine-protein kinase 22C
    spermiogenesis associated serine/threonine kinase 22D
    testis-specific kinase 3
    testis-specific serine/threonine kinase 3b
    NP_536690.1
    XP_006503317.1
    XP_030109549.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080442.2NP_536690.1  testis-specific serine/threonine-protein kinase 3

      See identical proteins and their annotated locations for NP_536690.1

      Status: VALIDATED

      Source sequence(s)
      AK019840
      Consensus CDS
      CCDS18693.1
      UniProtKB/Swiss-Prot
      Q9D2E1, Q9JL98
      Related
      ENSMUSP00000000421.6, ENSMUST00000000421.6
      Conserved Domains (1) summary
      cd14163
      Location:9265
      STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129382801..129385523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253689.1XP_030109549.1  testis-specific serine/threonine-protein kinase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9D2E1, Q9JL98
      Conserved Domains (1) summary
      cd14163
      Location:9265
      STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins
    2. XM_006503254.4XP_006503317.1  testis-specific serine/threonine-protein kinase 3 isoform X2

      See identical proteins and their annotated locations for XP_006503317.1

      Conserved Domains (1) summary
      cl21453
      Location:1190
      PKc_like; Protein Kinases, catalytic domain
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