Pla2g3 phospholipase A2, group III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g3provided by MGI
Official Full Name: phospholipase A2, group IIIprovided by MGI
Primary source: MGI:MGI:2444945
See related: Ensembl:ENSMUSG00000034579 AllianceGenome:MGI:2444945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sPLA2-III
Summary: Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including positive regulation of histamine secretion by mast cell; positive regulation of mast cell differentiation; and positive regulation of prostaglandin biosynthetic process. Acts upstream of or within several processes, including negative regulation of amyloid-beta clearance; regulation of gene expression; and spermatid development. Predicted to be located in centriole and recycling endosome. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 2.6), frontal lobe adult (RPKM 2.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.45 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3438158..3449346)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3488158..3499346)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain.
Title: Secreted PLA(2)-III is a possible therapeutic target to treat neuropathic pain.
Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2 Impairs Mast Cell Maturation and Functions.
Title: Mast Cell-Specific Deletion of Group III Secreted Phospholipase A(2) Impairs Mast Cell Maturation and Functions.
Here the authors have found that sPLA2-III-null (Pla2g3 (-/-)) mice are highly resistant to colon carcinogenesis. Furthermore, Pla2g3 (-/-) mice are less susceptible to dextran sulfate-induced colitis, implying that the amelioration of colonic inflammation by sPLA2-III ablation may underlie the protective effect against colon cancer.
Title: Group III phospholipase A(2) promotes colitis and colorectal cancer.
Findings show a key role of Pla2g3 on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 is involved in the initiation and/or progression of Alzheimer disease.
Title: Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme.
Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation.
Title: Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
the atypical sPLA2 family member sPLA2-III has a role in epididymal lipid homeostasis and its perturbation may lead to sperm dysfunction
Title: Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
This study showed that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that transgenic mice overexpressing human PLA2G3 spontaneously develop skin inflammation.
Title: Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
sPLA(2)-III may have a role in cancer development by stimulating tumor cell growth and angiogenesis
Title: Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipase A2 activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipoxygenase pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macrophage activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylcholine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of histamine secretion by mast cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within production of molecular mediator involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: group 3 secretory phospholipase A2

Names: GIII sPLA2; group III secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 3

NP_766379.2

EC 3.1.1.4

XP_006514752.1

EC 3.1.1.4

XP_006514753.1

EC 3.1.1.4

XP_006514754.1

EC 3.1.1.4

XP_030101817.1

EC 3.1.1.4

XP_036012542.1

EC 3.1.1.4

XP_036012543.1

EC 3.1.1.4

XP_036012544.1

EC 3.1.1.4

XP_036012545.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172791.2 → NP_766379.2 group 3 secretory phospholipase A2 precursor

See identical proteins and their annotated locations for NP_766379.2

Status: VALIDATED

Source sequence(s)

AK033572, BC079556

Consensus CDS

CCDS48740.1

UniProtKB/Swiss-Prot

Q8BZT7

UniProtKB/TrEMBL

Q6AXH0

Related

ENSMUSP00000068699.7, ENSMUST00000064265.13

Conserved Domains (2) summary

cd04704
Location:147 → 243

PLA2_bee_venom_like; A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of ...

cd04705
Location:295 → 422

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

3438158..3449346

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514689.4 → XP_006514752.1 group 3 secretory phospholipase A2 isoform X1

UniProtKB/TrEMBL

Q8BV23

Conserved Domains (2) summary

cd04704
Location:147 → 243

PLA2_bee_venom_like; A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of ...

cd04705
Location:295 → 422

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...
XM_006514691.4 → XP_006514754.1 group 3 secretory phospholipase A2 isoform X3

UniProtKB/TrEMBL

Q8BV23

Conserved Domains (2) summary

cd04704
Location:147 → 243

PLA2_bee_venom_like; A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of ...

cd04705
Location:295 → 422

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...
XM_006514690.4 → XP_006514753.1 group 3 secretory phospholipase A2 isoform X2

UniProtKB/TrEMBL

Q6AXH0

Conserved Domains (2) summary

cd04705
Location:250 → 377

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

cl05417
Location:147 → 232

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
XM_036156649.1 → XP_036012542.1 group 3 secretory phospholipase A2 isoform X4

UniProtKB/TrEMBL

Q8BV23

Conserved Domains (2) summary

cd04705
Location:250 → 377

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

cl05417
Location:147 → 232

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
XM_036156651.1 → XP_036012544.1 group 3 secretory phospholipase A2 isoform X6

Conserved Domains (1) summary

cd04705
Location:165 → 238

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...
XM_036156652.1 → XP_036012545.1 group 3 secretory phospholipase A2 isoform X8

Conserved Domains (1) summary

cd04705
Location:165 → 238

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...
XM_036156650.1 → XP_036012543.1 group 3 secretory phospholipase A2 isoform X5

Conserved Domains (2) summary

cd04705
Location:163 → 290

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

cl05417
Location:36 → 111

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
XM_030245957.2 → XP_030101817.1 group 3 secretory phospholipase A2 isoform X7

Related

ENSMUST00000151860.2

Conserved Domains (1) summary

cd04705
Location:68 → 195

PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...