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    Wsb1 WD repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78889, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wsb1provided by MGI
    Official Full Name
    WD repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1926139
    See related
    Ensembl:ENSMUSG00000017677 AllianceGenome:MGI:1926139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110056B13Rik; 2700038M07Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein K27-linked ubiquitination. Acts upstream of or within protein aggregate center assembly. Located in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 127.9), CNS E14 (RPKM 125.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wsb1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79130208..79145521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79239382..79254709, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene STARR-positive B cell enhancer ABC_E5253 Neighboring gene predicted gene, 30413 Neighboring gene STARR-seq mESC enhancer starr_30112 Neighboring gene predicted gene, 30470 Neighboring gene STARR-seq mESC enhancer starr_30114 Neighboring gene STARR-positive B cell enhancer ABC_E10697 Neighboring gene predicted gene, 30561 Neighboring gene STARR-seq mESC enhancer starr_30117 Neighboring gene neurofibromin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis. Chong L, et al. Am J Pathol, 2024 May. PMID 38325552
    2. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. Werneck de Castro JP, et al. J Clin Invest, 2015 Feb. PMID 25555216, Free PMC Article
    3. WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation. Kim JJ, et al. Cell Res, 2017 Feb. PMID 27958289, Free PMC Article
    4. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. Choi DW, et al. J Biol Chem, 2008 Feb 22. PMID 18093972
    5. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nucifora FC Jr, et al. Nat Commun, 2016 Jun 7. PMID 27273569, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis.
      Title: WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis.
    2. WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.
      Title: WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.
    3. WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2).
      Title: The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K27-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein aggregate center assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein aggregate center assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat and SOCS box-containing protein 1
    Names
    WD-40-repeat-containing protein with a SOCS box 1
    WSB-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042565.3 → NP_001036030.1  WD repeat and SOCS box-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001036030.1

      Status: VALIDATED

      Source sequence(s)
      AI644176, AK048511, BG069536
      UniProtKB/TrEMBL
      Q8C841, Q8VE81
      Related
      ENSMUST00000150416.8
      Conserved Domains (3) summary
      sd00039
      Location:17 → 57
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140 → 178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:1 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_019653.3 → NP_062627.3  WD repeat and SOCS box-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062627.3

      Status: VALIDATED

      Source sequence(s)
      AK167394, BB431254, BY097910
      Consensus CDS
      CCDS25118.1
      UniProtKB/Swiss-Prot
      O54927
      UniProtKB/TrEMBL
      Q3TFQ2, Q3TIA1, Q3U7R9, Q7TMU2
      Related
      ENSMUSP00000017821.6, ENSMUST00000017821.12
      Conserved Domains (4) summary
      COG2319
      Location:139 → 382
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:135 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:174 → 212
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:382 → 420
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79130208..79145521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157103.1 → XP_036012996.1  WD repeat and SOCS box-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8C841, Q8VE81
      Conserved Domains (3) summary
      sd00039
      Location:17 → 57
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140 → 178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:1 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54927.1 GenPept UniProtKB/Swiss-Prot:O54927

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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