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    Lrrc46 leucine rich repeat containing 46 [ Mus musculus (house mouse) ]

    Gene ID: 69297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc46provided by MGI
    Official Full Name
    leucine rich repeat containing 46provided by MGI
    Primary source
    MGI:MGI:1916547
    See related
    Ensembl:ENSMUSG00000020878 AllianceGenome:MGI:1916547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700006D24Rik
    Summary
    Is expressed in 4th ventricle lateral recess; lateral ventricle choroid plexus; and olfactory epithelium. Orthologous to human LRRC46 (leucine rich repeat containing 46). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 330.8) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc46 in Genome Data Viewer
    Location:
    11 D; 11 60.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96925428..96932195, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97034602..97041369, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene trans-acting transcription factor 6 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene predicted gene 11532 Neighboring gene secernin 2 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene STARR-positive B cell enhancer ABC_E8445 Neighboring gene oxysterol binding protein-like 7 Neighboring gene predicted gene, 51917

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of LRRC46 as a novel candidate gene for high myopia. Jiang L, et al. Sci China Life Sci, 2024 Sep. PMID 38874710
    2. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. Yin Y, et al. Int J Mol Sci, 2022 Jul 31. PMID 35955660, Free PMC Article
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of LRRC46 as a novel candidate gene for high myopia.
      Title: Identification of LRRC46 as a novel candidate gene for high myopia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027026.2 → NP_081302.2  leucine-rich repeat-containing protein 46

      See identical proteins and their annotated locations for NP_081302.2

      Status: PROVISIONAL

      Source sequence(s)
      BC022723
      Consensus CDS
      CCDS25311.1
      UniProtKB/Swiss-Prot
      Q8R1Z3, Q9DAP0
      Related
      ENSMUSP00000021251.7, ENSMUST00000021251.7
      Conserved Domains (2) summary
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:60 → 146
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96925428..96932195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAP0.2 GenPept UniProtKB/Swiss-Prot:Q9DAP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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