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    Agbl2 ATP/GTP binding protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 271813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agbl2provided by MGI
    Official Full Name
    ATP/GTP binding protein-like 2provided by MGI
    Primary source
    MGI:MGI:2443254
    See related
    Ensembl:ENSMUSG00000040812 AllianceGenome:MGI:2443254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCP2; 4930524K04; A430081C19Rik
    Summary
    Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Located in cytosol. Is expressed in brain; early embryo; genitourinary system; heart; and liver. Orthologous to human AGBL2 (AGBL carboxypeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 15.6), cerebellum adult (RPKM 1.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Agbl2 in Genome Data Viewer
    Location:
    2 E1; 2 50.37 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90613029..90664781)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90782685..90834437)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleoporin 160 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene formin binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene mitochondrial carrier 2 Neighboring gene C1q and tumor necrosis factor related protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Wang T, et al. Mol Cell Neurosci, 2006 Oct. PMID 16952463
    2. A novel subfamily of mouse cytosolic carboxypeptidases. Kalinina E, et al. FASEB J, 2007 Mar. PMID 17244818
    3. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Liu B, et al. Nat Commun, 2017 Aug 10. PMID 28794449, Free PMC Article
    4. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
    5. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Xia P, et al. Nat Immunol, 2016 Apr. PMID 26829768

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues.
      Title: The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein side chain deglutamylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein side chain deglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase 2
    Names
    carboxypeptidase 2, cytosolic
    protein deglutamylase CCP2
    NP_001343462.1
    NP_848870.2
    XP_006499692.1
    XP_006499693.1
    XP_006499694.1
    XP_006499695.1
    XP_006499696.1
    XP_006499697.1
    XP_006499702.1
    XP_006499703.1
    XP_006499705.1
    XP_006499706.1
    XP_006499707.1
    XP_006499708.1
    XP_006499709.1
    XP_006499711.1
    XP_011237881.1
    XP_017174416.1
    XP_030107540.1
    XP_036018155.1
    XP_036018156.1
    XP_036018157.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356533.1 → NP_001343462.1  cytosolic carboxypeptidase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct N-terminus and a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL714026
      Consensus CDS
      CCDS89512.1
      UniProtKB/TrEMBL
      A0A0B4J1L6
      Related
      ENSMUSP00000047936.5, ENSMUST00000037206.11
      Conserved Domains (1) summary
      cd06907
      Location:370 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

    2. NM_178755.4 → NP_848870.2  cytosolic carboxypeptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_848870.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK029744, AK029932
      Consensus CDS
      CCDS38177.2
      UniProtKB/Swiss-Prot
      A2AH35, Q09M08, Q09M09, Q09M10, Q09M11, Q09M12, Q8C529, Q8C9X4, Q8CDE6, Q8CDF6, Q8CDK2, Q8CDQ1
      UniProtKB/TrEMBL
      A0A0B4J1L6
      Related
      ENSMUSP00000048647.6, ENSMUST00000037219.12
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    RNA

    1. NR_151502.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK029744, AL714026
      Related
      ENSMUST00000051831.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90613029..90664781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499630.3 → XP_006499693.1  cytosolic carboxypeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006499693.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    2. XM_006499632.2 → XP_006499695.1  cytosolic carboxypeptidase 2 isoform X2

      See identical proteins and their annotated locations for XP_006499695.1

      UniProtKB/Swiss-Prot
      A2AH35, Q09M08, Q09M09, Q09M10, Q09M11, Q09M12, Q8C529, Q8C9X4, Q8CDE6, Q8CDF6, Q8CDK2, Q8CDQ1
      UniProtKB/TrEMBL
      A0A0B4J1L6
      Related
      ENSMUSP00000129216.2, ENSMUST00000170320.8
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    3. XM_006499640.1 → XP_006499703.1  cytosolic carboxypeptidase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    4. XM_006499643.1 → XP_006499706.1  cytosolic carboxypeptidase 2 isoform X9

      See identical proteins and their annotated locations for XP_006499706.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:361 → 611
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:213 → 340
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    5. XM_006499642.3 → XP_006499705.1  cytosolic carboxypeptidase 2 isoform X10

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    6. XM_036162264.1 → XP_036018157.1  cytosolic carboxypeptidase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    7. XM_036162263.1 → XP_036018156.1  cytosolic carboxypeptidase 2 isoform X5

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    8. XM_030251680.2 → XP_030107540.1  cytosolic carboxypeptidase 2 isoform X5

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Related
      ENSMUST00000149037.8
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    9. XM_036162262.1 → XP_036018155.1  cytosolic carboxypeptidase 2 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:361 → 611
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:213 → 340
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    10. XM_011239579.3 → XP_011237881.1  cytosolic carboxypeptidase 2 isoform X9

      See identical proteins and their annotated locations for XP_011237881.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:361 → 611
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:213 → 340
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    11. XM_006499646.4 → XP_006499709.1  cytosolic carboxypeptidase 2 isoform X13

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:316 → 566
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:168 → 295
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    12. XM_006499631.4 → XP_006499694.1  cytosolic carboxypeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006499694.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    13. XM_006499629.4 → XP_006499692.1  cytosolic carboxypeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006499692.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    14. XM_017318927.3 → XP_017174416.1  cytosolic carboxypeptidase 2 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    15. XM_006499639.4 → XP_006499702.1  cytosolic carboxypeptidase 2 isoform X7

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    16. XM_006499644.4 → XP_006499707.1  cytosolic carboxypeptidase 2 isoform X11

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    17. XM_006499634.4 → XP_006499697.1  cytosolic carboxypeptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:361 → 611
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:213 → 340
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    18. XM_006499645.4 → XP_006499708.1  cytosolic carboxypeptidase 2 isoform X12

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:316 → 566
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:168 → 295
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    19. XM_006499633.4 → XP_006499696.1  cytosolic carboxypeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006499696.1

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    20. XM_006499648.5 → XP_006499711.1  cytosolic carboxypeptidase 2 isoform X14

      UniProtKB/TrEMBL
      A0A0B4J1L6
      Related
      ENSMUSP00000115632.2, ENSMUST00000136058.8
      Conserved Domains (2) summary
      cd06907
      Location:379 → 629
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:231 → 358
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    RNA

    1. XR_866286.1 RNA Sequence

    2. XR_866284.3 RNA Sequence

    3. XR_001782954.3 RNA Sequence

    4. XR_004940620.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDK2.1 GenPept UniProtKB/Swiss-Prot:Q8CDK2

    Gene LinkOut

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