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    Cdc123 cell division cycle 123 [ Mus musculus (house mouse) ]

    Gene ID: 98828, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc123provided by MGI
    Official Full Name
    cell division cycle 123provided by MGI
    Primary source
    MGI:MGI:2138811
    See related
    Ensembl:ENSMUSG00000039128 AllianceGenome:MGI:2138811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G431001I09Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein folding chaperone. Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly. Predicted to be active in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.7), CNS E11.5 (RPKM 25.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc123 in Genome Data Viewer
    Location:
    2 A1; 2 3.62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5799105..5849988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5794294..5845177, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase ID Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5534743-5534896 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5572598-5572785 Neighboring gene STARR-seq mESC enhancer starr_03568 Neighboring gene STARR-seq mESC enhancer starr_03570 Neighboring gene STARR-seq mESC enhancer starr_03571 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5661717-5662018 Neighboring gene STARR-seq mESC enhancer starr_03574 Neighboring gene predicted gene, 29857 Neighboring gene STARR-seq mESC enhancer starr_03576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene predicted gene, 29984 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene nudix hydrolase 5 Neighboring gene predicted gene 13199 Neighboring gene SEC61 translocon subunit alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein folding chaperone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 2 complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eukaryotic translation initiation factor 2 complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF2 assembly protein
    Names
    cell division cycle 123 homolog
    cell division cycle protein 123 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356501.1 → NP_001343430.1  translation initiation factor eIF2 assembly protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL928924
      Conserved Domains (1) summary
      pfam07065
      Location:14 → 303
      D123; D123

    2. NM_001356502.1 → NP_001343431.1  translation initiation factor eIF2 assembly protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL928924
      Conserved Domains (1) summary
      pfam07065
      Location:14 → 273
      D123; D123

    3. NM_001356503.1 → NP_001343432.1  translation initiation factor eIF2 assembly protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK161246, AL928924
      Conserved Domains (1) summary
      pfam07065
      Location:14 → 167
      D123; D123

    4. NM_001356504.1 → NP_001343433.1  translation initiation factor eIF2 assembly protein isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL928924
      Conserved Domains (1) summary
      pfam07065
      Location:14 → 156
      D123; D123

    5. NM_133837.5 → NP_598598.1  translation initiation factor eIF2 assembly protein isoform 1

      See identical proteins and their annotated locations for NP_598598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK159208, AL928924
      Consensus CDS
      CCDS15666.1
      UniProtKB/Swiss-Prot
      Q3TTR0, Q8CII2, Q8VE51
      Related
      ENSMUSP00000043033.4, ENSMUST00000043864.9
      Conserved Domains (1) summary
      pfam07065
      Location:14 → 314
      D123; D123

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      5799105..5849988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252263.2 → XP_030108123.1  translation initiation factor eIF2 assembly protein isoform X1

      Conserved Domains (1) summary
      pfam07065
      Location:14 → 262
      D123
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CII2.2 GenPept UniProtKB/Swiss-Prot:Q8CII2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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