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    Cfap77 cilia and flagella associated protein 77 [ Mus musculus (house mouse) ]

    Gene ID: 329375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap77provided by MGI
    Official Full Name
    cilia and flagella associated protein 77provided by MGI
    Primary source
    MGI:MGI:2685669
    See related
    Ensembl:ENSMUSG00000079502 AllianceGenome:MGI:2685669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm823; 1700101E01Rik
    Summary
    Is active in axonemal B tubule inner sheath. Orthologous to human CFAP77 (cilia and flagella associated protein 77). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 7.0), ovary adult (RPKM 1.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap77 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28845493..28945078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28955481..29055066, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BarH like homeobox 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28916086-28916195 Neighboring gene STARR-seq mESC enhancer starr_04036 Neighboring gene STARR-seq mESC enhancer starr_04037 Neighboring gene transcription termination factor, RNA polymerase I Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 77

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166705.1 → NP_001160177.1  cilia- and flagella-associated protein 77

      See identical proteins and their annotated locations for NP_001160177.1

      Status: VALIDATED

      Source sequence(s)
      BB647135, BC147761
      Consensus CDS
      CCDS50551.1
      UniProtKB/Swiss-Prot
      A0A087WRI3, B2RWG1
      Related
      ENSMUSP00000125742.2, ENSMUST00000157048.4
      Conserved Domains (1) summary
      pfam14825
      Location:56 → 203
      DUF4483; Domain of unknown function (DUF4483)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28845493..28945078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001085514.2: Suppressed sequence

      Description
      NM_001085514.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A087WRI3.1 GenPept UniProtKB/Swiss-Prot:A0A087WRI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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