Snx10 sorting nexin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx10provided by MGI
Official Full Name: sorting nexin 10provided by MGI
Primary source: MGI:MGI:1919232
See related: Ensembl:ENSMUSG00000038301 AllianceGenome:MGI:1919232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410004M09Rik
Summary: Predicted to enable 1-phosphatidylinositol binding activity; ATPase binding activity; and phosphatidylinositol phosphate binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Is expressed in chondrocranium; incisor; limb; and nose. Used to study autosomal recessive osteopetrosis 8. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 11.5), cortex adult (RPKM 10.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 24.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (51500882..51567659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (51523900..51590679)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice.
Title: SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice.
SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
Title: SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
Title: Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
Title: Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
Title: Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
Title: An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
Title: Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
Title: Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
Title: SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
Title: FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

Snx10 (e-PCR), detects polymorphism
- UniSTS:498450

Snx10 (e-PCR), detects polymorphism
- UniSTS:498357

A003A21 (e-PCR)
- UniSTS:36573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization involved in bone maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tooth eruption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
colocalizes_with centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of endosome membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sorting nexin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127348.1 → NP_001120820.1 sorting nexin-10 isoform a

See identical proteins and their annotated locations for NP_001120820.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AK028163, AK150878, AK151320, AK166121

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Related

ENSMUSP00000136974.2, ENSMUST00000179365.8

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001127349.1 → NP_001120821.1 sorting nexin-10 isoform a

See identical proteins and their annotated locations for NP_001120821.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AK150878, AK151320

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Related

ENSMUSP00000044165.9, ENSMUST00000049152.15

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361576.1 → NP_001348505.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Related

ENSMUSP00000117914.2, ENSMUST00000137212.8

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361577.1 → NP_001348506.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361578.1 → NP_001348507.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361579.1 → NP_001348508.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361580.1 → NP_001348509.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361581.1 → NP_001348510.1 sorting nexin-10 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AC153877

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
NM_001361582.1 → NP_001348511.1 sorting nexin-10 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC153877

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7

Conserved Domains (1) summary

cl02563
Location:1 → 69

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_028035.4 → NP_082311.3 sorting nexin-10 isoform a

See identical proteins and their annotated locations for NP_082311.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).

Source sequence(s)

AK028163, AK150878, AK151320

Consensus CDS

CCDS20136.1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Related

ENSMUSP00000110082.2, ENSMUST00000114439.8

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

51500882..51567659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255600.2 → XP_030111460.1 sorting nexin-10 isoform X1

UniProtKB/Swiss-Prot

Q8C1E0, Q9CWT3

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7, Q4FJX6

Conserved Domains (1) summary

cd06898
Location:12 → 109

PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
XM_036152314.1 → XP_036008207.1 sorting nexin-10 isoform X2

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7

Conserved Domains (1) summary

cl02563
Location:1 → 69

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_036152316.1 → XP_036008209.1 sorting nexin-10 isoform X2

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7

Conserved Domains (1) summary

cl02563
Location:1 → 69

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_011241474.1 → XP_011239776.1 sorting nexin-10 isoform X2

See identical proteins and their annotated locations for XP_011239776.1

UniProtKB/TrEMBL

Q3U6V6, Q3U746, Q3UBN7

Conserved Domains (1) summary

cl02563
Location:1 → 69

PX_domain; The Phox Homology domain, a phosphoinositide binding module