Klrk1 killer cell lectin-like receptor subfamily K, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrk1provided by MGI
Official Full Name: killer cell lectin-like receptor subfamily K, member 1provided by MGI
Primary source: MGI:MGI:1196250
See related: Ensembl:ENSMUSG00000030149 AllianceGenome:MGI:1196250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nkg2d; NKG2-D; D6H12S2489E
Summary: Enables several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of natural killer cell mediated cytotoxicity. Acts upstream of or within several processes, including positive regulation of biosynthetic process; response to bacterium; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in tropical spastic paraparesis. Orthologous to several human genes including KLRK1 (killer cell lectin like receptor K1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129587286..129600863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129610323..129623903, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice.
Title: NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice.
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
Title: NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
IL-17a-producing gammadeltaT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.
Title: IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.
CD8[+] T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
Title: CD8(+) T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.
Title: TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.
Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Title: Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival.
Title: Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival.
Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy.
Title: Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy.
The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.
Title: The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.
NKG2D Enhances Double-Negative T Cell Regulation of B Cells.
Title: NKG2D Enhances Double-Negative T Cell Regulation of B Cells.

Submit: New GeneRIF Correction See all GeneRIFs (149)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6H12S2489E (e-PCR), detects polymorphism
- UniSTS:142578

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class Ib receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within natural killer cell activation	IPI Inferred from Physical Interaction more info	PubMed
involved_in natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of natural killer cell chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid dendritic cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stimulatory C-type lectin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: NKG2-D type II integral membrane protein

Names: NK cell receptor D; NKG2-D-activating NK receptor; natural killer cell group 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083322.2 → NP_001076791.1 NKG2-D type II integral membrane protein isoform b

See identical proteins and their annotated locations for NP_001076791.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AC171002, AF030313, BY207066

Consensus CDS

CCDS39661.1

UniProtKB/TrEMBL

Q2TJJ6

Related

ENSMUSP00000093061.5, ENSMUST00000095412.10

Conserved Domains (1) summary

cd03593
Location:102 → 216

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001286018.1 → NP_001272947.1 NKG2-D type II integral membrane protein isoform c

See identical proteins and their annotated locations for NP_001272947.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which contains a distinct N-terminus and an additional internal in-frame segment, and is shorter, compared to isoform a.

Source sequence(s)

AC171002

Consensus CDS

CCDS71846.1

UniProtKB/TrEMBL

Q2TJJ6, Q3TCW7

Related

ENSMUSP00000130398.2, ENSMUST00000168919.8

Conserved Domains (2) summary

cd03593
Location:108 → 222

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

PHA03097
Location:70 → 223

PHA03097; C-type lectin-like protein; Provisional
NM_033078.4 → NP_149069.1 NKG2-D type II integral membrane protein isoform a

See identical proteins and their annotated locations for NP_149069.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AA174479, AC171002, AK040436

Consensus CDS

CCDS39660.1

UniProtKB/Swiss-Prot

O54709

UniProtKB/TrEMBL

Q2TJJ6, Q4FJM0

Related

ENSMUSP00000032252.6, ENSMUST00000032252.8

Conserved Domains (1) summary

cd03593
Location:115 → 229

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129587286..129600863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255429.2 → XP_030111289.1 NKG2-D type II integral membrane protein isoform X2

Conserved Domains (1) summary

cd03593
Location:102 → 180

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_011241369.4 → XP_011239671.1 NKG2-D type II integral membrane protein isoform X1

UniProtKB/TrEMBL

Q2TJJ6

Conserved Domains (1) summary

cd03593
Location:115 → 193

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)