Palm3 paralemmin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Palm3provided by MGI
Official Full Name: paralemmin 3provided by MGI
Primary source: MGI:MGI:1921587
See related: Ensembl:ENSMUSG00000047986 AllianceGenome:MGI:1921587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4432412L15Rik
Summary: Predicted to enable ATP binding activity. Predicted to be involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. Is expressed in gut; nervous system; and urinary system. Orthologous to human PALM3 (paralemmin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 12.0), thymus adult (RPKM 3.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.25 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84747787..84757300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84021157..84030671)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PALM3 contributes to the development of acute lung injury in mice challenged with lipopolysaccharide.
Title: Silencing of Paralemmin-3 Protects Mice from lipopolysaccharide-induced acute lung injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Toll signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paralemmin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028877.2 → NP_083153.1 paralemmin-3

See identical proteins and their annotated locations for NP_083153.1

Status: VALIDATED

Source sequence(s)

AC156028

Consensus CDS

CCDS40405.1

UniProtKB/Swiss-Prot

A2TJV2, Q9CRS0

Related

ENSMUSP00000051396.7, ENSMUST00000055077.7

Conserved Domains (2) summary

PRK03427
Location:574 → 720

PRK03427; cell division protein ZipA; Provisional

TIGR00927
Location:378 → 646

2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

84747787..84757300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312990.3 → XP_017168479.1 paralemmin-3 isoform X2

Conserved Domains (1) summary

PHA03324
Location:20 → 87

PHA03324; nuclear egress membrane protein UL34; Provisional
XM_030243816.2 → XP_030099676.1 paralemmin-3 isoform X1

Conserved Domains (1) summary

TIGR00927
Location:257 → 516

2A1904; K+-dependent Na+/Ca+ exchanger