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    caiC carnitine--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944886, updated on 3-Dec-2024

    Summary

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    Official Symbol
    caiC
    Official Full Name
    carnitine--CoA ligase
    Primary source
    ECOCYC:EG11558
    Locus tag
    b0037
    See related
    ASAP:ABE-0000133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0038; yaaM
    Summary
    Simliarity comparisons with Salmonella, Desulfotomaculum, Shewanella and Proteus CaiC homologs indicate that the second ATG is the likely start site, which also has a good predicted RBS of GGAG (Personal communication, G. [More information is available at EcoGene: EG11558]. Carnitine-CoA ligase (CaiC) catalyzes the transfer of CoA to carnitine. [More information is available at EcoCyc: EG11558].
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    Genomic context

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    Sequence:
    NC_000913.3 (36271..37824, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transferase CaiE Neighboring gene crotonobetainyl-CoA hydratase Neighboring gene gamma-butyrobetainyl-CoA:carnitine CoA transferase Neighboring gene crotonobetainyl-CoA reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redirecting metabolic fluxes through cofactor engineering: Role of CoA-esters pool during L(-)-carnitine production by Escherichia coli. Bernal V, et al. J Biotechnol, 2007 Oct 31. PMID 17617487
    2. Role of wet experiment design in data generation: from in vivo to in silico and back. Cánovas M, et al. In Silico Biol, 2007. PMID 17822388
    3. Regulation of the carnitine pathway in Escherichia coli: investigation of the cai-fix divergent promoter region. Buchet A, et al. J Bacteriol, 1998 May. PMID 9573142, Free PMC Article
    4. Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli. Eichler K, et al. J Bacteriol, 1996 Mar. PMID 8631699, Free PMC Article
    5. A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Zaslaver A, et al. Nat Methods, 2006 Aug. PMID 16862137

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables CoA-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-thiol ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnitine-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables crotonobetaine-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables crotonobetaine-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables crotonobetaine-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carnitine--CoA ligase
    NP_414579.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      36271..37824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414579.4 carnitine--CoA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414579.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8NG67
      Conserved Domains (1) summary
      PRK08008
      Location:1 → 517
      caiC; putative crotonobetaine/carnitine-CoA ligase; Validated
    Nucleotide Protein
    Heading Accession and Version

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