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    paaZ fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945954, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaZ
    Official Full Name
    fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase
    Primary source
    ECOCYC:G6708
    Locus tag
    b1387
    See related
    ASAP:ABE-0004644
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1384; maoC; ydbN
    Summary
    MaoC is involved in supplying (R)-3-hydroxyacyl-CoA from the beta-oxidation pathway to the PHA biosynthetic pathway, in fadB mutants. [More information is available at EcoGene: EG13735]. PaaZ is a putative ring-cleavage enzyme involved in phenylacetate catabolism . [More information is available at EcoCyc: G6708].
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    Genomic context

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    Sequence:
    NC_000913.3 (1451597..1453642, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetaldehyde dehydrogenase Neighboring gene copper-containing amine oxidase Neighboring gene phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway. Sathyanarayanan N, et al. Nat Commun, 2019 Sep 11. PMID 31511507, Free PMC Article
    2. Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point. Teufel R, et al. J Biol Chem, 2011 Apr 1. PMID 21296885, Free PMC Article
    3. A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene. Sugino H, et al. J Bacteriol, 1992 Apr. PMID 1556068, Free PMC Article
    4. The monoamine regulon including syntheses of arylsulfatase and monoamine oxidase in bacteria. Murooka Y, et al. Biosci Biotechnol Biochem, 1996 Jun. PMID 8695909
    5. Identification and characterization of a new enoyl coenzyme A hydratase involved in biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli. Park SJ, et al. J Bacteriol, 2003 Sep. PMID 12949091, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enoyl-CoA hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ether hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase
    NP_415905.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1451597..1453642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415905.1 fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415905.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WVP1
      Conserved Domains (1) summary
      PRK11563
      Location:1 → 674
      PRK11563; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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