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    prpR DNA-binding transcriptional dual regulator PrpR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944987, updated on 3-Dec-2024

    Summary

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    Official Symbol
    prpR
    Official Full Name
    DNA-binding transcriptional dual regulator PrpR
    Primary source
    ECOCYC:G6195
    Locus tag
    b0330
    See related
    ASAP:ABE-0001133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0328; yahP
    Summary
    Crp regulon. [More information is available at EcoGene: EG13600]. PrpR (propinate regulator) is a member of the 54-dependent activator family and participates in controlling several genes involved in propionate catabolism. [More information is available at EcoCyc: G6195].
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    Genomic context

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    Sequence:
    NC_000913.3 (346857..348443, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative amino acid exporter YahN Neighboring gene DUF1471 domain-containing protein YahO Neighboring gene 2-methylisocitrate lyase Neighboring gene 2-methylcitrate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In a class of its own--the RNA polymerase sigma factor sigma 54 (sigma N). Merrick MJ. Mol Microbiol, 1993 Dec. PMID 7934866
    2. Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon. Ishida Y, et al. J Bacteriol, 2009 Oct. PMID 19633077, Free PMC Article
    3. Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein. Lee SK, et al. J Bacteriol, 2005 Apr. PMID 15805526, Free PMC Article
    4. 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. Palacios S, et al. Microbiology (Reading), 2004 Nov. PMID 15528672
    5. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Horswill AR, et al. J Bacteriol, 1999 Sep. PMID 10482501, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in propionate catabolic process, 2-methylcitrate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator PrpR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      346857..348443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414864.1 DNA-binding transcriptional dual regulator PrpR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414864.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7S353
      Conserved Domains (1) summary
      PRK15424
      Location:1 → 528
      PRK15424; propionate catabolism operon regulatory protein PrpR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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