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    glmM phosphoglucosamine mutase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947692, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glmM
    Official Full Name
    phosphoglucosamine mutase
    Primary source
    ECOCYC:EG11553
    Locus tag
    b3176
    See related
    ASAP:ABE-0010439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3165; mrsA; yhbF
    Summary
    Autophosphorylated enzyme (at Ser-102) is active form. glmM is an essential gene. [More information is available at EcoGene: EG11553]. Phosphoglucosamine mutase catalyzes the interconversion of the glucosamine-6-phosphate (GlcN-6-P) and glucosamine-1-phosphate (GlcN-1-P) isomers. [More information is available at EcoCyc: EG11553].
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    Genomic context

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    Sequence:
    NC_000913.3 (3322733..3324070, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Sec translocon subunit SecG Neighboring gene dihydropteroate synthase Neighboring gene ATP-dependent zinc metalloprotease FtsH Neighboring gene 23S rRNA 2'-O-ribose U2552 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophosphorylation of phosphoglucosamine mutase from Escherichia coli. Jolly L, et al. J Bacteriol, 2000 Mar. PMID 10671448, Free PMC Article
    2. Reaction mechanism of phosphoglucosamine mutase from Escherichia coli. Jolly L, et al. Eur J Biochem, 1999 May. PMID 10231382
    3. The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome. Dallas WS, et al. J Bacteriol, 1993 Dec. PMID 8244950, Free PMC Article
    4. Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Kumar JK, et al. Proc Natl Acad Sci U S A, 2004 Mar 16. PMID 15004283, Free PMC Article
    5. The diversity of lysine-acetylated proteins in Escherichia coli. Yu BJ, et al. J Microbiol Biotechnol, 2008 Sep. PMID 18852508

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucosamine mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglucosamine mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoglucosamine mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomannomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoglucosamine mutase
    NP_417643.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3322733..3324070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417643.1 phosphoglucosamine mutase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417643.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6P939
      Conserved Domains (1) summary
      PRK10887
      Location:4 → 445
      glmM; phosphoglucosamine mutase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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