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    eae T3SS intimin [ Escherichia coli O157:H7 str. Sakai ]

    Gene ID: 915471, updated on 1-Apr-2024

    Summary

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    Gene symbol
    eae
    Gene description
    T3SS intimin
    Locus tag
    ECs_4559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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    Genomic context

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    Sequence:
    NC_002695.2 (4596583..4599387, complement)

    NC_002695.2Genomic Context describing neighboring genes Neighboring gene T3SS secretion switching protein SepL Neighboring gene T3SS structure protein EscD Neighboring gene T3SS chaperone CesT Neighboring gene T3SS translocated intimin receptor Tir

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002695.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland. Wang L, et al. Toxins (Basel), 2023 Nov 23. PMID 38133173, Free PMC Article
    2. Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence. Girard F, et al. Infect Immun, 2005 Sep. PMID 16113321, Free PMC Article
    3. Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding. Bai X, et al. Front Cell Infect Microbiol, 2018. PMID 29765909, Free PMC Article
    4. Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. Sinclair JF, et al. J Biol Chem, 2004 Aug 6. PMID 15173179
    5. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA. McNeilly TN, et al. PLoS One, 2015. PMID 26020530, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland.
      Title: Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland.
    2. The presence of stx2 in stool could be used as risk predictor at an early stage. Shiga toxin-producing Escherichia coli isolates with stx2 toxin and intimin protein were significantly associated with bloody diarrhea.
      Title: Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding.
    3. intimins and invasins represent a very small minority of the sequence diversity in what has been previously the "intimin/invasin protein family
      Title: Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.
    4. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA
      Title: Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA.
    5. influences intestinal adherence and tropism of attaching and effecing E. coli (AEEC) strains
      Title: Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    T3SS intimin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002695.2 Reference assembly

      Range
      4596583..4599387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_312586.1 T3SS intimin [Escherichia coli O157:H7 str. Sakai]

      See identical proteins and their annotated locations for NP_312586.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      B5ARQ5
      Conserved Domains (5) summary
      smart00634
      Location:659 → 743
      BID_1; Bacterial Ig-like domain (group 1)
      smart00635
      Location:758 → 836
      BID_2; Bacterial Ig-like domain 2
      pfam07979
      Location:839 → 934
      Intimin_C; Intimin C-type lectin domain
      pfam01476
      Location:65 → 113
      LysM; LysM domain
      pfam11924
      Location:169 → 442
      IAT_beta; Inverse autotransporter, beta-domain
    Nucleotide Protein
    Heading Accession and Version

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