envC murein hydrolase activator EnvC [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: envC
Official Full Name: murein hydrolase activator EnvC
Primary source: ECOCYC:EG12297
Locus tag: b3613
See related: ASAP:ABE-0011820
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3603; slm11; yibP
Summary: NlpD, YgeR, YebA and EnvC are paralogs. envC is a synthetic lethal with minCDE. [More information is available at EcoGene: EG12297]. EnvC has murein hydrolytic activity and also shows weak protease activity toward beta-casein . [More information is available at EcoCyc: EG12297].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Consistent with its role as a regulator, the active-site region is degenerate and lacks a catalytic metal ion.
Title: Structure-function analysis of the LytM domain of EnvC, an activator of cell wall remodelling at the Escherichia coli division site.
The authors report that AmiB and EnvC are recruited to division sites independently of one another. The same is also true for AmiC and NlpD.
Title: A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators.

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Function	Evidence Code	Pubs
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidoglycan-based cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septum digestion after cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within septum digestion after cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell division site	IDA Inferred from Direct Assay more info	PubMed
located_in outer membrane-bounded periplasmic space	IDA Inferred from Direct Assay more info	PubMed
located_in periplasmic space	IDA Inferred from Direct Assay more info	PubMed
located_in periplasmic space	IEA Inferred from Electronic Annotation more info
located_in periplasmic space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed