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Links from GEO Profiles

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    Osm oncostatin M [ Mus musculus (house mouse) ]

    Gene ID: 18413, updated on 4-Jan-2025

    Summary

    Official Symbol
    Osmprovided by MGI
    Official Full Name
    oncostatin Mprovided by MGI
    Primary source
    MGI:MGI:104749
    See related
    Ensembl:ENSMUSG00000058755 AllianceGenome:MGI:104749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OncoM
    Summary
    Enables cytokine activity. Acts upstream of or within several processes, including negative regulation of meiotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; and tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in several structures, including aorta-gonad-mesonephros; future spinal cord; genitourinary system; submandibular gland; and trophectoderm. Orthologous to human OSM (oncostatin M). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 1.9), thymus adult (RPKM 1.8) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Osm in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4186831..4191027)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4236785..4241026)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10a Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956 Neighboring gene STARR-seq mESC enhancer starr_28372 Neighboring gene STARR-seq mESC enhancer starr_28375 Neighboring gene leukemia inhibitory factor Neighboring gene predicted gene 11959

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables growth factor activity  
    enables oncostatin-M receptor binding  
    enables oncostatin-M receptor binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral response to pain PubMed 
    involved_in immune response  
    acts_upstream_of meiotic nuclear division PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion  
    acts_upstream_of_or_within negative regulation of meiotic nuclear division PubMed 
    involved_in oncostatin-M-mediated signaling pathway  
    involved_in oncostatin-M-mediated signaling pathway  
    acts_upstream_of_or_within peripheral nervous system development PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of inflammatory response  
    acts_upstream_of positive regulation of interleukin-17 production  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within response to heat PubMed 
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
    Component Evidence Code Pubs
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013365.3NP_001013383.1  oncostatin-M precursor

      See identical proteins and their annotated locations for NP_001013383.1

      Status: VALIDATED

      Source sequence(s)
      AL807825
      Consensus CDS
      CCDS24382.1
      UniProtKB/Swiss-Prot
      P53347, Q3U1Y5, Q5SPX6
      Related
      ENSMUSP00000074708.3, ENSMUST00000075221.3
      Conserved Domains (2) summary
      pfam01291
      Location:43194
      LIF_OSM; LIF / OSM family
      pfam02956
      Location:191249
      TT_ORF1; TT viral orf 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4186831..4191027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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