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    Dlgap3 DLG associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 242667, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlgap3provided by MGI
    Official Full Name
    DLG associated protein 3provided by MGI
    Primary source
    MGI:MGI:3039563
    See related
    Ensembl:ENSMUSG00000042388 AllianceGenome:MGI:3039563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAP3; DAP-3; Prpl8; Sapap3
    Summary
    Enables amyloid-beta binding activity. Involved in modification of postsynaptic structure and modulation of chemical synaptic transmission. Located in synapse. Is active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in corpus striatum. Orthologous to human DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 35.9), frontal lobe adult (RPKM 29.7) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dlgap3 in Genome Data Viewer
    Location:
    4 D2.2; 4 61.33 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (127062090..127130815)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127168305..127237022)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35B Neighboring gene STARR-seq mESC enhancer starr_11422 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11423 Neighboring gene STARR-seq mESC enhancer starr_11425 Neighboring gene STARR-seq mESC enhancer starr_11428 Neighboring gene predicted gene, 52707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:126920065-126920248 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:126920954-126921137 Neighboring gene small integral membrane protein 12 Neighboring gene predicted gene, 22221

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cholinergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disks large-associated protein 3
    Names
    PSD-95/SAP90-binding protein 3
    SAP90/PSD 95 associated protein 3
    discs, large homolog-associated protein 3
    prion protein ligand 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302081.2NP_001289010.1  disks large-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001289010.1

      Status: VALIDATED

      Source sequence(s)
      AL606984
      Consensus CDS
      CCDS18665.1
      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
      Related
      ENSMUSP00000101700.3, ENSMUST00000106094.9
      Conserved Domains (2) summary
      PHA03418
      Location:515607
      PHA03418; hypothetical E4 protein; Provisional
      pfam03359
      Location:626977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. NM_001426291.1NP_001413220.1  disks large-associated protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606984
      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
    3. NM_001426292.1NP_001413221.1  disks large-associated protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606984
      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
    4. NM_001426293.1NP_001413222.1  disks large-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606984
      UniProtKB/TrEMBL
      B1AS06
      Related
      ENSMUSP00000101698.2, ENSMUST00000106092.2
    5. NM_001426294.1NP_001413223.1  disks large-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606984
      UniProtKB/TrEMBL
      B1AS06
    6. NM_001426295.1NP_001413224.1  disks large-associated protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606984
    7. NM_198618.6NP_941020.1  disks large-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_941020.1

      Status: VALIDATED

      Source sequence(s)
      AL606984
      Consensus CDS
      CCDS18665.1
      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
      Related
      ENSMUSP00000039724.8, ENSMUST00000046659.14
      Conserved Domains (2) summary
      PHA03418
      Location:515607
      PHA03418; hypothetical E4 protein; Provisional
      pfam03359
      Location:626977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      127062090..127130815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164130.1XP_036020023.1  disks large-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
      Conserved Domains (2) summary
      PHA03418
      Location:515607
      PHA03418; hypothetical E4 protein; Provisional
      pfam03359
      Location:626977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. XM_011240537.3XP_011238839.1  disks large-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011238839.1

      UniProtKB/Swiss-Prot
      Q6PDX0, Q6PFD5, Q6XBF2
      UniProtKB/TrEMBL
      Q3TY61
      Conserved Domains (2) summary
      PHA03418
      Location:515607
      PHA03418; hypothetical E4 protein; Provisional
      pfam03359
      Location:626977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein