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    Megf6 multiple EGF-like-domains 6 [ Mus musculus (house mouse) ]

    Gene ID: 230971, updated on 9-Dec-2024

    Summary

    Official Symbol
    Megf6provided by MGI
    Official Full Name
    multiple EGF-like-domains 6provided by MGI
    Primary source
    MGI:MGI:1919351
    See related
    Ensembl:ENSMUSG00000057751 AllianceGenome:MGI:1919351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Egfl3; 2600001P17Rik
    Summary
    Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including embryo mesenchyme; head bone; intraembryonic coelom; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 18.7), limb E14.5 (RPKM 18.6) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Megf6 in Genome Data Viewer
    Location:
    4 E2; 4 83.89 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154255156..154360178)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154170704..154275721)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene transformation related protein 63 regulated 1 like Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene predicted gene, 52687 Neighboring gene STARR-seq mESC enhancer starr_12232 Neighboring gene PR domain containing 16 Neighboring gene VISTA enhancer mm1087 Neighboring gene STARR-seq mESC enhancer starr_12235 Neighboring gene predicted gene, 52688

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC49785

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    multiple epidermal growth factor-like domains protein 6
    Names
    EGF-like protein 3
    EGF-like-domain, multiple 3
    epidermal growth factor-like protein 3
    multiple EGF-like domains protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162977.1NP_001156449.1  multiple epidermal growth factor-like domains protein 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL627123
      Consensus CDS
      CCDS51398.1
      UniProtKB/TrEMBL
      A0A0A0MQ83
      Related
      ENSMUSP00000030897.9, ENSMUST00000030897.15
      Conserved Domains (3) summary
      pfam07546
      Location:42111
      EMI; EMI domain
      pfam14670
      Location:337372
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:153201
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154255156..154360178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250240.2XP_011248542.1  multiple epidermal growth factor-like domains protein 6 isoform X2

      Conserved Domains (3) summary
      pfam07546
      Location:42111
      EMI; EMI domain
      pfam14670
      Location:337372
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:153201
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_006538826.3XP_006538889.1  multiple epidermal growth factor-like domains protein 6 isoform X1

      Conserved Domains (3) summary
      pfam07546
      Location:42111
      EMI; EMI domain
      pfam14670
      Location:296331
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:242283
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. XM_006538827.2XP_006538890.1  multiple epidermal growth factor-like domains protein 6 isoform X3

      Related
      ENSMUSP00000121641.2, ENSMUST00000152159.8
      Conserved Domains (2) summary
      pfam14670
      Location:229264
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:175216
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172273.1: Suppressed sequence

      Description
      NM_172273.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.